年龄相关性黄斑变性中息肉样病变的发展。
Development of polypoidal lesions in age-related macular degeneration.
机构信息
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
出版信息
Eye (Lond). 2011 Apr;25(4):481-8. doi: 10.1038/eye.2010.232. Epub 2011 Jan 21.
PURPOSE
To investigate the development of polypoidal lesions using indocyanine green angiography (IA) in eyes with typical age-related macular degeneration (AMD).
METHODS
We retrospectively reviewed the medical records of 47 consecutive patients (47 eyes) with typical AMD who had been followed up with IA for at least 2 years.
RESULTS
At the initial visit, although all eyes showed classic and/or occult choroidal neovascularization (CNV) associated with AMD, no eyes showed polypoidal lesions by IA. However, during follow-up, 13 (27.7%) of the 47 eyes did show polypoidal lesions. All polypoidal lesions developed at the edge of persistent CNV or, more often, at the terminus of recently progressed CNV. Of 12 eyes with a final lesion area >8 disc area, 7 (58.3%) showed newly developed polypoidal lesions. In the eyes with these newly developed polypoidal lesions, the mean area of the vascular lesion had extended significantly from 10.50 ± 7.88 mm² to 20.87 ± 10.21 mm² during follow-up (P=0.0018).
CONCLUSION
The current observation suggests that IA of active AMD sometimes reveals polypoidal lesions if there is progression of the CNV in the subretinal pigment epithelium space.
目的
利用吲哚菁绿血管造影（IA）观察典型年龄相关性黄斑变性（AMD）患者的息肉样病变的发展情况。
方法
我们回顾性分析了 47 例（47 只眼）连续的典型 AMD 患者的病历资料，这些患者至少接受了 2 年的 IA 随访。
结果
初次就诊时，虽然所有眼均显示与 AMD 相关的典型和/或隐匿性脉络膜新生血管（CNV），但 IA 并未显示息肉样病变。然而，在随访过程中，47 只眼中有 13 只（27.7%）出现了息肉样病变。所有息肉样病变均发生于持续性 CNV 的边缘，或更常见于新近进展的 CNV 的末端。在最终病变面积>8 个视盘面积的 12 只眼中，有 7 只（58.3%）出现了新的息肉样病变。在这些新出现息肉样病变的眼中，血管病变的平均面积在随访期间从 10.50±7.88mm²显著扩展至 20.87±10.21mm²（P=0.0018）。
结论
目前的观察结果表明，如果视网膜色素上皮下空间的 CNV 进展，IA 有时会显示出活跃的 AMD 中的息肉样病变。
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