Kumar Anil, Prakash Atish, Dogra Samrita
Pharmacology Division, University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University, Chandigarh, India.
J Asian Nat Prod Res. 2011 Jan;13(1):42-55. doi: 10.1080/10286020.2010.544253.
Brain senescence plays an important role in cognitive dysfunction and neurodegenerative disorders. Curcumin was reported to have beneficial effect against several neurodegenerative disorders including Alzheimer's disease. Therefore, the present study was conducted in order to explore the possible role of curcumin against D-galactose-induced cognitive dysfunction, oxidative damage, and mitochondrial dysfunction in mice. Chronic administration of D-galactose for 6 weeks significantly impaired cognitive function (both in Morris water maze and elevated plus maze), locomotor activity, oxidative defense (raised lipid peroxidation, nitrite concentration, depletion of reduced glutathione and catalase activity), and mitochondrial enzyme complex activities (I, II, and III) as compared to vehicle treated group. Curcumin (15 and 30 mg/kg) and galantamine (5 mg/kg) treatment for 6 weeks significantly improved cognitive tasks, locomotor activity, oxidative defense, and restored mitochondrial enzyme complex activity as compared to control (D-galactose). Chronic D-galactose treatment also significantly increased acetylcholine esterase activity that was attenuated by curcumin (15 and 30 mg/kg) and galantamine (5 mg/kg) treatment. In conclusion, the present study highlights the therapeutic potential of curcumin against d-galactose induced senescence in mice.
脑衰老在认知功能障碍和神经退行性疾病中起重要作用。据报道，姜黄素对包括阿尔茨海默病在内的多种神经退行性疾病具有有益作用。因此，本研究旨在探讨姜黄素对D-半乳糖诱导的小鼠认知功能障碍、氧化损伤和线粒体功能障碍的可能作用。与载体处理组相比，连续6周给予D-半乳糖显著损害认知功能（在莫里斯水迷宫和高架十字迷宫中均如此）、运动活动、氧化防御（脂质过氧化增加、亚硝酸盐浓度升高、还原型谷胱甘肽消耗和过氧化氢酶活性降低）以及线粒体酶复合物活性（I、II和III）。与对照组（D-半乳糖）相比，姜黄素（15和30mg/kg）和加兰他敏（5mg/kg）治疗6周显著改善了认知任务、运动活动、氧化防御，并恢复了线粒体酶复合物活性。长期D-半乳糖治疗还显著增加了乙酰胆碱酯酶活性，而姜黄素（15和30mg/kg）和加兰他敏（5mg/kg）治疗可使其减弱。总之，本研究突出了姜黄素对D-半乳糖诱导的小鼠衰老的治疗潜力。
