Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany.
Sleep Med. 2011 Feb;12(2):170-8. doi: 10.1016/j.sleep.2010.07.017. Epub 2011 Jan 21.
There is broad evidence that sleep as opposed to waking facilitates the consolidation of both declarative and procedural memory. The current study addressed the question whether different extents of sleep restriction after learning would impair long-term memory consolidation in adolescents.
Eighty-eight healthy adolescents were randomized to five different sleep protocols with 9, 8, 7, 6 or 5 h of time in bed for four consecutive nights under controlled conditions that excluded daytime sleep. Declarative (word-pair task) and procedural memory (mirror tracing task) encoding was assessed prior to the sleep restriction protocol. Recall was assessed after two recovery nights following the sleep protocol and 4 weeks later.
Sleep diaries and actigraphy data demonstrated that the participants closely followed the sleep protocols. There were no differences in demographic parameters or memory encoding at baseline. In contrast to the initial prediction, restriction of nocturnal sleep over four consecutive nights had no significant impact on declarative or procedural memory consolidation. Polysomnographic monitoring after sleep restriction demonstrated a high preservation of the amount of slow wave sleep in the restricted conditions.
The results suggest that adolescents show a high resilience of memory consolidation to substantial sleep curtailment across four nights that might be promoted by increased sleep intensity under conditions of sleep restriction.
有广泛的证据表明，与清醒相比，睡眠有利于陈述性记忆和程序性记忆的巩固。本研究探讨了学习后不同程度的睡眠限制是否会损害青少年的长期记忆巩固。
88 名健康青少年随机分为五组，每组在连续四晚的受控条件下有 9、8、7、6 或 5 小时的卧床时间，以排除白天睡眠。在睡眠限制协议之前，评估陈述性（单词对任务）和程序性记忆（镜像追踪任务）编码。在睡眠协议后的两个恢复晚上和 4 周后评估回忆。
睡眠日记和活动记录仪数据表明，参与者密切遵循了睡眠协议。在人口统计学参数或记忆编码方面没有差异。与最初的预测相反，连续四个晚上限制夜间睡眠对陈述性或程序性记忆的巩固没有显著影响。睡眠限制后的多导睡眠图监测显示，在限制条件下，慢波睡眠的量得到了很好的保留。
结果表明，青少年在四个晚上的睡眠限制下，记忆巩固具有很高的弹性，这可能是由于在睡眠限制条件下增加了睡眠强度而促进的。
