乙型肝炎病毒的X蛋白类似于一种丝氨酸蛋白酶抑制剂。
X protein of hepatitis B virus resembles a serine protease inhibitor.
作者信息
Takada S, Koike K
机构信息
Department of Gene Research, Cancer Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1990 Dec;81(12):1191-4. doi: 10.1111/j.1349-7006.1990.tb02675.x.
Abstract
The X protein of hepatitis B virus (HBV) has been shown to be a trans-activator for viral and cellular genes. Amino acid sequences in X protein were found to be highly homologous to functionally essential sequences in the "Kunitz domain," characteristic of Kunitz-type serine protease inhibitors. Mutations at these sequences completely abolished trans-activation. Consequently, HBV X protein resembles a serine protease inhibitor or its analogue, and may bring about trans-activation by activating certain transcriptional factors through proteolytic cleavage alteration.
摘要
乙型肝炎病毒（HBV）的X蛋白已被证明是病毒和细胞基因的反式激活因子。发现X蛋白中的氨基酸序列与Kunitz型丝氨酸蛋白酶抑制剂特有的“Kunitz结构域”中的功能必需序列高度同源。这些序列的突变完全消除了反式激活。因此，HBV X蛋白类似于丝氨酸蛋白酶抑制剂或其类似物，可能通过蛋白水解切割改变激活某些转录因子来实现反式激活。
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