Equine Hospital, Section Internal Medicine, Department for Small Animals and Horses, Vetmeduni Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Vet J. 2012 Jan;191(1):72-8. doi: 10.1016/j.tvjl.2010.12.010. Epub 2011 Jan 22.
The myeloperoxidase index (MPXI) was investigated as a diagnostic indicator of systemic inflammation in a retrospective study using data from 859 hospitalised horses. A reference interval of 8.5-10.4 for the MPXI was established. In horses with systemic inflammatory response syndrome (SIRS), the MPXI was significantly lower than in healthy horses, those with localised inflammation and those with sepsis. The MPXI in horses with sepsis was also significantly lower than in healthy animals and those with localised inflammation. Horses in the SIRS group with leucopenia, white blood cell (WBC) count within the reference interval (WRI) or leucocytosis had significantly lower MPXIs than healthy horses, those with localised inflammation and those with sepsis in the same WBC count subgroups. In horses with sepsis and WBC count WRI, the MPXI was significantly lower than in healthy horses or those with localised inflammation. MPXI is a useful complementary tool to identify horses with systemic inflammation, especially if they have WBC counts WRI.
本研究回顾性分析了 859 例住院马匹的数据，探讨了髓过氧化物酶指数（MPXI）作为全身炎症的诊断指标。建立了 MPXI 的参考区间为 8.5-10.4。患有全身炎症反应综合征（SIRS）的马匹的 MPXI 明显低于健康马匹、局部炎症马匹和脓毒症马匹。脓毒症马匹的 MPXI 也明显低于健康动物和局部炎症马匹。SIRS 组中性粒细胞减少、白细胞计数（WBC）在参考区间内（WRI）或白细胞增多的马匹的 MPXI 明显低于健康马匹、局部炎症马匹和同一 WBC 计数亚组的脓毒症马匹。在白细胞计数 WRI 的脓毒症马匹中，MPXI 明显低于健康马匹或局部炎症马匹。MPXI 是一种有用的辅助工具，可用于识别患有全身炎症的马匹，特别是当它们的白细胞计数处于参考区间内时。
