Meligy Bassant, Sayed Amal, Ismail Dalia Kadry, Kamal Dina, Abdel-Latif Walaa, Erfan Dina M
Pediatric Department, Faculty of Medicine, Cairo University, Egypt.
Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt.
Gaz Egypt Paediatr Assoc. 2016 Mar;64(1):13-19. doi: 10.1016/j.epag.2015.11.005. Epub 2015 Dec 30.
Acute lower respiratory tract infection in children causes significant morbidity in the developing countries. Documentation of virus infection using PCR and clinical characteristics of patients affected with viral pneumonia are reviewed in this study.
51 children less than three years admitted to the Pediatric Hospital, Cairo University with viral pneumonia were included. All patients had undergone nasopharyngeal aspirate for PCR viral detection.
A total of 51 cases were enrolled in the study, of which 7 cases were negative while 44 children were positive for viruses. The most common respiratory virus was Rhinovirus in 32 patients (72.2%), then parainfluenza virus (PIV) in 12 (27.3%), of which subtypes PIV1 were 2 (4.5%), PIV3 were 5 (11.4%) and PIV4 were 5 (11.4%) cases. The third common viruses were respiratory syncytial virus (RSV) in 9 (20.5%) cases of which 3 (6.8%) were RSVA and 6 (13.6%) were RSVB and adenovirus in 9 cases (20.5%). Boca virus was found in 8 (18.2%) patients, corona virus 2 (4.5%) patients, H1N1 2 (4.5%) patients, enterovirus 2 patients (4.5%) and human metapneumovirus in one case (2.3%). Influenza B and PIV2 were not detected. Coinfection was found in 28 (63.7%). Mortality occurred in 12 (23.5%). There was no significant relation between virus type or coinfection with disease severity.
RV was the most commonly detected virus in children under 3 years admitted with acute lower respiratory tract infections. Coinfection was present in the majority of our patients; however it was not related significantly to parameters of disease severity.
儿童急性下呼吸道感染在发展中国家导致了显著的发病率。本研究回顾了使用聚合酶链反应（PCR）记录病毒感染情况以及病毒肺炎患儿的临床特征。
纳入开罗大学儿童医院收治的51例3岁以下的病毒性肺炎患儿。所有患者均接受了鼻咽抽吸物的PCR病毒检测。
本研究共纳入51例病例，其中7例检测结果为阴性，44例患儿病毒检测呈阳性。最常见的呼吸道病毒是鼻病毒，共32例（72.2%），其次是副流感病毒（PIV），共12例（27.3%），其中PIV1亚型2例（4.5%），PIV3亚型5例（11.4%），PIV4亚型5例（11.4%）。第三常见的病毒是呼吸道合胞病毒（RSV），共9例（20.5%），其中RSVA 3例（6.8%），RSVB 6例（13.6%），腺病毒9例（20.5%）。8例（18.2%）患者检测到博卡病毒，2例（4.5%）患者检测到冠状病毒，2例（4.5%）患者检测到H1N1，2例（4.5%）患者检测到肠道病毒，1例（2.3%）患者检测到人间质肺炎病毒。未检测到乙型流感病毒和PIV2。28例（63.7%）存在合并感染。12例（23.5%）发生死亡。病毒类型或合并感染与疾病严重程度之间无显著关系。
在因急性下呼吸道感染入院的3岁以下儿童中，鼻病毒是最常检测到的病毒。大多数患者存在合并感染；然而，合并感染与疾病严重程度参数无显著相关性。
