双光束相分辨多普勒光学相干断层扫描术对微血管系统的可视化
Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography.
作者信息
Zotter Stefan, Pircher Michael, Torzicky Teresa, Bonesi Marco, Götzinger Erich, Leitgeb Rainer A, Hitzenberger Christoph K
机构信息
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
出版信息
Opt Express. 2011 Jan 17;19(2):1217-27. doi: 10.1364/OE.19.001217.
Abstract
We present a dual-beam Doppler optical coherence tomography system for visualizing the microvasculature within the retina. The sample arm beams from two identical spectral domain optical coherence tomography (SD-OCT) systems are combined such that there is a small horizontal offset between them at the retina. Thereby we record two tomograms which are slightly separated in time. Phase-resolved Doppler analysis is performed between these two data sets. This system allows blood capillary imaging with high flow sensitivity and variable velocity range. To demonstrate the performance of our system we present images of the microvascular network around the fovea and around the optic nerve head of the human eye.
摘要
我们展示了一种用于可视化视网膜内微血管系统的双光束多普勒光学相干断层扫描系统。来自两个相同光谱域光学相干断层扫描（SD-OCT）系统的样本臂光束被组合在一起，使得它们在视网膜处有一个小的水平偏移。由此我们记录了两个在时间上略有分离的断层图像。在这两个数据集之间进行相位分辨多普勒分析。该系统允许以高血流敏感性和可变速度范围对毛细血管进行成像。为了展示我们系统的性能，我们呈现了人眼黄斑中心凹周围和视神经乳头周围微血管网络的图像。
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2
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Opt Lett. 2010 May 1;35(9):1467-9. doi: 10.1364/OL.35.001467.
3
Scanning protocols dedicated to smart velocity ranging in spectral OCT.光谱光学相干断层扫描中用于智能速度范围测定的扫描协议。
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4
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