Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
PLoS One. 2011 Jan 14;6(1):e16190. doi: 10.1371/journal.pone.0016190.
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.
我们最近开发了用于活体测量骨骼结构皮质厚度的图像处理技术，其分辨率超过了基础计算机断层扫描系统。由此产生的厚度图可以通过统计参数映射进行跨队列分析。将这些方法应用于骨质疏松女性的近端股骨，我们发现药物骨质疏松治疗和习惯性机械负荷在增加骨厚度方面具有靶向和明显的协同作用。
