State Key Laboratory of Oncology in South China, 510060 Guangzhou, People's Republic of China.
Med Oncol. 2012 Jun;29(2):406-10. doi: 10.1007/s12032-011-9832-0. Epub 2011 Jan 25.
The aim of this study is to analyze the prognostic value of androgen receptor (AR) expression for patients with triple-negative breast cancer (TNBC). Clinical data of these patients were collected and analyzed, and immunohistochemical staining for AR was performed on tissue microarrays of operable breast cancer from 287 patients with TNBC, who were treated at Sun Yat-sen University Cancer Center from January 1995 to December 2008. AR expression was found in 25.8% of the cases with TNBC. TNBC patients with AR negative have a higher proportion of positive lymph node. A significant correlation was found between AR expression and disease-free survival (DFS) and overall survival (OS). Univariated analysis indicated that AR expression had a significant prognostic value in TNBC patients, whereas multivariate analysis indicated that AR was a significant independent prognostic factor of DFS (P = 0.032) in all patients. Our results suggested that AR was a favorable prognostic factor of DFS and OS in patients with TNBC. Therefore, TNBC may be further divided into two subtypes according to AR status.
本研究旨在分析雄激素受体（AR）表达对三阴性乳腺癌（TNBC）患者的预后价值。收集这些患者的临床资料并进行分析，对中山大学肿瘤防治中心 1995 年 1 月至 2008 年 12 月收治的 287 例可手术治疗的 TNBC 患者的组织微阵列进行 AR 免疫组织化学染色。结果发现 25.8%的 TNBC 患者存在 AR 表达。AR 阴性的 TNBC 患者淋巴结阳性比例更高。AR 表达与无病生存（DFS）和总生存（OS）之间存在显著相关性。单因素分析表明，AR 表达对 TNBC 患者具有显著的预后价值，而多因素分析表明，AR 是所有患者 DFS 的显著独立预后因素（P=0.032）。我们的结果表明，AR 是 TNBC 患者 DFS 和 OS 的有利预后因素。因此，TNBC 可能根据 AR 状态进一步分为两个亚型。
