Stefanini Marianne O, Qutub Amina A, Mac Gabhann Feilim, Popel Aleksander S
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Math Med Biol. 2012 Mar;29(1):85-94. doi: 10.1093/imammb/dqq025. Epub 2011 Jan 25.
Tumour angiogenesis allows a growing mass of cancer cells to overcome oxygen diffusion limitation and to increase cell survival. The growth of capillaries from pre-existing blood vessels is the result of numerous signalling cascades involving different molecules and of cellular events involving multiple cell and tissue types. Computational models offer insight into the mechanisms governing angiogenesis and provide quantitative information on parameters difficult to assess by experiments alone. In this article, we summarize results from computational models of tumour angiogenic processes with a focus on the molecular-detailed vascular endothelial growth factor-associated models that have been developed in our laboratory, spanning multiple scales from the molecular to whole body.
肿瘤血管生成使不断增长的癌细胞团能够克服氧扩散限制并提高细胞存活率。从已有的血管中生长出毛细血管是众多涉及不同分子的信号级联反应以及涉及多种细胞和组织类型的细胞事件的结果。计算模型有助于深入了解血管生成的调控机制，并提供仅凭实验难以评估的参数的定量信息。在本文中，我们总结了肿瘤血管生成过程计算模型的结果，重点关注我们实验室开发的与血管内皮生长因子相关的分子细节模型，这些模型跨越了从分子到全身的多个尺度。
