Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Diabetes Care. 2011 Feb;34(2):468-70. doi: 10.2337/dc10-1222.
We examined the relationship between the presence and extent of coronary stenosis and carotid intima-media thickness (CIMT) in type 2 diabetic patients without history of coronary artery disease (CAD) but with carotid atherosclerosis.
A total of 91 type 2 diabetic patients underwent multi-slice computed tomography coronary angiography.
Max-IMT in the ≥ 50% stenosis group by multi-slice computed tomography coronary angiography estimation was significantly greater than the 0-25 and 25-50% stenosis group (2.68 ± 0.77 vs. 1.61 ± 0.49 mm, P < 0.0005, and 2.14 ± 0.81 mm, P < 0.05, respectively), and max-IMT in the 25-50% stenosis group was significantly greater than the 0-25% stenosis group (P < 0.05) after adjustment for age, sex, duration of type 2 diabetes, hypertension, and dyslipidemia. In the analysis for trend through the categories of max-IMT, as max-IMT increased, the percentage of ≥ 50% stenosis increased and the percentage of 0-25% stenosis decreased.
Our data suggest that max-IMT might be closely associated with the extent of coronary stenosis in type 2 diabetic patients without history of CAD but with carotid atherosclerosis.
我们研究了无冠心病（CAD）病史但伴有颈动脉粥样硬化的 2 型糖尿病患者中冠状动脉狭窄的存在和程度与颈动脉内膜中层厚度（CIMT）之间的关系。
共有 91 名 2 型糖尿病患者接受了多层螺旋 CT 冠状动脉造影检查。
多层螺旋 CT 冠状动脉造影估计的≥50%狭窄组的最大 IMT 明显大于 0-25%和 25-50%狭窄组（2.68±0.77 vs. 1.61±0.49 mm，P<0.0005 和 2.14±0.81 mm，P<0.05），并且在调整年龄、性别、2 型糖尿病病程、高血压和血脂异常后，25-50%狭窄组的最大 IMT 明显大于 0-25%狭窄组（P<0.05）。在通过最大 IMT 分类进行趋势分析时，随着最大 IMT 的增加，≥50%狭窄的百分比增加，而 0-25%狭窄的百分比减少。
我们的数据表明，在无 CAD 病史但伴有颈动脉粥样硬化的 2 型糖尿病患者中，最大 IMT 可能与冠状动脉狭窄的程度密切相关。
