Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Cell Cycle. 2011 Feb 1;10(3):441-8. doi: 10.4161/cc.10.3.14710.
MicroRNAs (miRNAs) have emerged as critical regulators of numerous biological processes by modulating gene expression at the post-transcriptional level. It has become increasingly clear that almost all aspects of skeletal muscle development involve regulation by miRNAs. Many of these miRNAs have distinct expression profiles in skeletal muscles, under the regulation by the myogenic program. In the last few years the field has seen a rapid expansion of our knowledge of myogenic miRNAs that target a wide range of muscle genes to coordinately control the myogenic process. In this review we provide an up-to-date list of reported myogenic miRNAs and survey their expression patterns, regulation of biogenesis, and gene targets in skeletal muscles. Emerging themes of miRNA regulation in the context of skeletal myogenesis will also be discussed.
微小 RNA（miRNAs）通过在转录后水平调节基因表达，成为许多生物学过程的关键调控因子。越来越明显的是，几乎骨骼肌发育的所有方面都涉及 miRNA 的调节。在肌生成程序的调控下，许多 miRNA 在骨骼肌中有独特的表达谱。在过去的几年中，我们对肌生成 miRNA 的认识迅速扩展，这些 miRNA 靶向广泛的肌肉基因，协调控制肌生成过程。在这篇综述中，我们提供了一份报告的肌生成 miRNA 的最新清单，并调查了它们在骨骼肌中的表达模式、生物发生的调节和基因靶标。还将讨论 miRNA 在骨骼肌生成中的调节的新兴主题。
