Sakuraba Kazuma, Yokomizo Kazuaki, Shirahata Atsushi, Goto Tetsuhiro, Saito Mitsuo, Ishibashi Kazuyoshi, Kigawa Gaku, Nemoto Hiroshi, Hibi Kenji
Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan.
Anticancer Res. 2011 Jan;31(1):77-9.
Recently, it has been shown that the loss of the human histone acetyl transferase, TIP60, led to an accumulation of double-strand DNA breaks and has been linked to a growing number of cancer types.
TIP60 expression levels were examined in 46 gastric cancer samples using a quantitative real-time polymerase chain reaction (QRT-PCR). Subsequently, clinicopathological data were correlated with the TIP60 expression score.
A down-regulation of the TIP60 gene was observed in 28 out of 46 (61%) specimens of primary gastric cancer. TIP60 down-regulation showed significant correlation with patient age (p=0.0224), depth of tumor invasion (p=0.0401) and lymph node metastasis (p=0.0481).
The down-regulation of TIP60 is important for the malignant pathway of gastric carcinogenesis.
最近研究表明，人类组蛋白乙酰转移酶TIP60的缺失会导致双链DNA断裂的积累，并且与越来越多的癌症类型相关。
使用定量实时聚合酶链反应（QRT-PCR）检测46例胃癌样本中的TIP60表达水平。随后，将临床病理数据与TIP60表达评分进行关联。
在46例原发性胃癌标本中的28例（61%）中观察到TIP60基因下调。TIP60下调与患者年龄（p=0.0224）、肿瘤浸润深度（p=0.0401）和淋巴结转移（p=0.0481）显著相关。
TIP60的下调对胃癌发生的恶性途径很重要。
