Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Food and Nutrition Policy and Planning Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Science, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran.
Eur J Nutr. 2024 Mar;63(2):425-433. doi: 10.1007/s00394-023-03275-w. Epub 2023 Nov 16.
This study was conducted to examine the effects of daily intake of γ-oryzanol (ORZ)-fortified canola oil, as compared with plain canola and sunflower oils, on certain inflammatory and oxidative stress biomarkers in adult subjects with Type 2 Diabetes (T2D).
We randomly allocated 92 adult subjects with T2D from both sexes to one of the following groups to receive: (a) ORZ-fortified canola oil (ORZO; n = 30); (b) unfortified canola oil (CANO; n = 32); or (c) sunflower oil (SUFO; n = 30) for 12 weeks. Dietary and laboratory evaluations were performed initially and finally.
Serum hs-CRP concentrations significantly decreased in ORZO group (from 3.1 ± 0.2 to 1.2 ± 0.2 mg/L), as compared with CANO (p = 0.003) and SUFO (p < 0.001) groups. Serum IL-6 significantly decreased just in ORZO (- 22.8%, p = 0.042) and CANO groups (- 19.8%, p = 0.038). However, the between-group differences were not significant. Serum IL-1β slightly decreased in ORZO (- 28.1%, p = 0.11) and increased in SUFO (+ 20.6%, p = 0.079) but between-group difference was statistically significant (p = 0.017). Serum IFN-γ concentrations decreased significantly only in ORZO (from 3.3 ± 0.08 to 2.9 ± 0.21 IU/mL, p = 0.044). Salivary IgA concentrations increased significantly in all three intervention groups. Notwithstanding, only the difference between ORZO and CANO groups was statistically significant (p = 0.042). Similarly, circulating malondialdehyde concentrations significantly decreased in all three groups but with no between-group significant difference.
Daily consumption of ORZ-fortified canola oil, compared with unfortified canola and sunflower oils, for 12 weeks resulted in boosting of certain anti-inflammatory effects of canola oil. These findings may have preventive implications for both clinicians and policy makers. This clinical trial was registered at clinicaltrials.gov (03.08.2022; NCT05271045).
本研究旨在检验与普通菜籽油和葵花籽油相比，每日摄入富含γ-谷维素（ORZ）的菜籽油对 2 型糖尿病（T2D）成年患者某些炎症和氧化应激生物标志物的影响。
我们随机将 92 名 T2D 成年患者（男女不限）分配至以下三组之一，接受以下处理：（a）富含 ORZ 的菜籽油（ORZO；n=30）；（b）未强化的菜籽油（CANO；n=32）；或（c）葵花籽油（SUFO；n=30），共 12 周。最初和最后分别进行膳食和实验室评估。
与 CANO（p=0.003）和 SUFO（p<0.001）组相比，ORZO 组血清 hs-CRP 浓度显著降低（从 3.1±0.2 降至 1.2±0.2mg/L）。ORZO（-22.8%，p=0.042）和 CANO 组（-19.8%，p=0.038）血清 IL-6 显著降低。然而，组间差异无统计学意义。ORZO（-28.1%，p=0.11）和 SUFO 组（+20.6%，p=0.079）血清 IL-1β 略有降低，但组间差异有统计学意义（p=0.017）。仅 ORZO 组血清 IFN-γ 浓度显著降低（从 3.3±0.08 降至 2.9±0.21IU/mL，p=0.044）。所有三组的唾液 IgA 浓度均显著升高，但仅 ORZO 和 CANO 组间差异有统计学意义（p=0.042）。同样，所有三组循环丙二醛浓度均显著降低，但组间无显著差异。
与食用未强化菜籽油和葵花籽油相比，每日食用富含 ORZ 的菜籽油 12 周可增强菜籽油的某些抗炎作用。这些发现可能对临床医生和决策者具有预防意义。这项临床试验在 clinicaltrials.gov 上注册（2022 年 3 月 8 日；NCT05271045）。
