Institute of Infectious Diseases and Molecular Medicine, Division of Immunology, CLS, University of Cape Town, Cape Town, South Africa.
Mamm Genome. 2011 Feb;22(1-2):55-65. doi: 10.1007/s00335-010-9277-3. Epub 2010 Aug 11.
The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
近年来，由于免疫功能低下人群的增加，真菌感染的临床相关性显著增加，人们对理解保护性免疫的潜在机制重新产生了兴趣。在这里，我们回顾了参与抗真菌免疫的模式识别受体 Dectin-1，并讨论了最近发现的编码该受体的基因多态性导致人类疾病的情况。
