Dectin-1：在抗真菌防御中的作用以及人类遗传多态性的后果。
Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans.
机构信息
Institute of Infectious Diseases and Molecular Medicine, Division of Immunology, CLS, University of Cape Town, Cape Town, South Africa.
出版信息
Mamm Genome. 2011 Feb;22(1-2):55-65. doi: 10.1007/s00335-010-9277-3. Epub 2010 Aug 11.
The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
近年来，由于免疫功能低下人群的增加，真菌感染的临床相关性显著增加，人们对理解保护性免疫的潜在机制重新产生了兴趣。在这里，我们回顾了参与抗真菌免疫的模式识别受体 Dectin-1，并讨论了最近发现的编码该受体的基因多态性导致人类疾病的情况。
Zotero 插件