Armstrong M Y, Ebenstein P, Konigsberg W H, Richards F F
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4549-52. doi: 10.1073/pnas.75.9.4549.
Plasmacytomas are induced in BALB/c mice by the intraperitoneal injection of pristane (2,6,10,14-tetra-methylpentadecane) after a latent period of six months and more [Anderson, P. N. & Potter, M. (1969) Nature 222, 994-995]. Spleen cells mesenteric lymph node cells, thoracic lymph node cells, and peritoneal exudate cells were prepared from pristane-treated and control uninjected BALB/c mice during the course of a 10-month period, and these cell suspensions were tested for the release of infectious murine leukemia viruses. Endogenous ecotropic and xenotropic murine leukemia viruses were expressed in pristane-treated mice during the latter part of the tumor induction period, in those cell populations in which transformed plasma cells appear, namely, peritoneal exudate cells and thoracic lymph node cells. The significance of preferential expression of both ecotropic and xenotropic murine leukemia virus in target cell populations following the administration of a carcinogen is discussed in terms of the possible formation of an oncogenic variant virus.
通过腹腔注射 pristane（2,6,10,14 - 四甲基十五烷），在六个月及更长的潜伏期后，可在 BALB/c 小鼠中诱发浆细胞瘤[安德森，P. N. & 波特，M.（1969 年）《自然》222 卷，994 - 995 页]。在 10 个月的时间里，从经 pristane 处理的和未注射的对照 BALB/c 小鼠中制备脾细胞、肠系膜淋巴结细胞、胸段淋巴结细胞和腹腔渗出细胞，并检测这些细胞悬液中传染性小鼠白血病病毒的释放情况。在肿瘤诱导期后期，在出现转化浆细胞的细胞群体中，即腹腔渗出细胞和胸段淋巴结细胞中，内源性亲嗜性和异嗜性小鼠白血病病毒在经 pristane 处理的小鼠中表达。就致癌变体病毒的可能形成而言，讨论了在给予致癌物后靶细胞群体中亲嗜性和异嗜性小鼠白血病病毒优先表达的意义。
