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SLC11A1（NRAMP1）多态性与结核病易感性：更新的系统评价和荟萃分析。

SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis.

机构信息

State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

PLoS One. 2011 Jan 25;6(1):e15831. doi: 10.1371/journal.pone.0015831.

DOI:10.1371/journal.pone.0015831
PMID:21283567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3026788/
Abstract

BACKGROUND

Natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has been described to regulate macrophage activation and be associated with infectious and autoimmune diseases. The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations.

METHODS

We systematically reviewed published studies on SLC11A1 polymorphisms and tuberculosis susceptibility until September 15, 2010 and quantitatively summarized associations of the most widely studied polymorphisms using meta-analysis.

RESULTS

In total, 36 eligible articles were included in this review. In Meta-analysis, significant associations were observed between tuberculosis risk and widely studied SLC11A1 polymorphisms with summarized odds ratio of 1.35 (95%CI, 1.17-1.54), 1.25 (95% CI, 1.04-1.50), 1.23 (95% CI, 1.04-1.44), 1.31 (95%CI, 1.08-1.59) for 3' UTR, D543N, INT4, and 5' (GT)n, respectively. Heterogeneity between studies was not pronounced, and the associations did not remarkably vary in the stratified analysis with respect to study population and study base.

CONCLUSIONS

The association between SLC11A1 polymorphisms and tuberculosis susceptibility observed in our analyses supports the hypothesis that NRAMP1 might play an important role in the host defense to the development of tuberculosis.

摘要

背景

自然抗性相关巨噬细胞蛋白 1（NRAMP1）由 SLC11A1 基因编码，已被描述为调节巨噬细胞激活，并与感染和自身免疫性疾病相关。SLC11A1 多态性与结核病易感性之间的关系已在不同人群中进行了研究。

方法

我们系统地回顾了截至 2010 年 9 月 15 日发表的关于 SLC11A1 多态性与结核病易感性的研究，并使用荟萃分析定量总结了最广泛研究的多态性的相关性。

结果

共有 36 篇符合条件的文章被纳入本综述。在荟萃分析中，广泛研究的 SLC11A1 多态性与结核病风险之间存在显著相关性，汇总的优势比分别为 1.35（95%可信区间，1.17-1.54）、1.25（95%可信区间，1.04-1.50）、1.23（95%可信区间，1.04-1.44）、1.31（95%可信区间，1.08-1.59）。对于 3'UTR、D543N、INT4 和 5'（GT）n。研究之间的异质性不明显，并且在按研究人群和研究基础进行分层分析时，相关性没有显著变化。

结论

我们分析中观察到的 SLC11A1 多态性与结核病易感性之间的关联支持了 NRAMP1 可能在宿主防御结核病发展中发挥重要作用的假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/71bd34883a5b/pone.0015831.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/745b06ec0d15/pone.0015831.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/003229684d62/pone.0015831.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/b91e3f62ffdb/pone.0015831.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/4beaf0532efa/pone.0015831.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/71bd34883a5b/pone.0015831.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/745b06ec0d15/pone.0015831.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/003229684d62/pone.0015831.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/b91e3f62ffdb/pone.0015831.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/4beaf0532efa/pone.0015831.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f675/3026788/71bd34883a5b/pone.0015831.g005.jpg

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