Athanasou N A, Chaplin A J, Oliver D O
University of Oxford Nuffield Department of Pathology, John Radcliffe Hospital, UK.
Nephrol Dial Transplant. 1990;5(10):878-81. doi: 10.1093/ndt/5.10.878.
Subcutaneous deposition of beta 2-microglobulin (beta 2-M) amyloid is an uncommon finding in uraemic patients on long-term haemodialysis. A 60-year-old female on haemodialysis for 16 years developed a subcutaneous haematoma 2 years prior to death. At necropsy the lesion contained numerous deposits of beta 2-M amyloid as well as evidence of old haemorrhage, fibrous repair, dystrophic calcification and calcium oxalate crystal deposition. Highly sulphated glycosaminoglycans were present in the amyloid deposits. beta 2-M amyloid deposits were also present in the hip joint, cervical and lumbar spine, and in small blood vessels of the heart, liver, and lung. The possible role of trauma and tissue glycosaminoglycans changes in the formation of subcutaneous amyloid tumours is discussed.
β2-微球蛋白（β2-M）淀粉样蛋白的皮下沉积在长期血液透析的尿毒症患者中并不常见。一名60岁女性，血液透析16年，在死亡前2年出现皮下血肿。尸检时，病变处含有大量β2-M淀粉样蛋白沉积物，以及陈旧性出血、纤维修复、营养不良性钙化和草酸钙晶体沉积的证据。淀粉样蛋白沉积物中存在高度硫酸化的糖胺聚糖。髋关节、颈椎和腰椎以及心脏、肝脏和肺的小血管中也存在β2-M淀粉样蛋白沉积物。本文讨论了创伤和组织糖胺聚糖变化在皮下淀粉样瘤形成中的可能作用。
