Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Pharm Biol. 2011 Jun;49(6):553-62. doi: 10.3109/13880209.2010.528432. Epub 2011 Feb 1.
To investigate transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid in the semipurified fraction isolated from Terminalia chebula Retz. (Combretaceae) galls.
Nonelastic and elastic niosomes loaded with gallic acid in pure form or in the semipurified fraction were developed. Rat skin permeation by vertical Franz diffusion cells of gallic acid from various gel formulations containing elastic niosomes loaded with gallic acid or the semipurified fraction was performed.
Elastic and nonelastic niosomes loaded with gallic acid or the semipurified fraction exhibited the mixture of unilamellar and multilamellar structures with negative zeta potential values and in the size range of 200-400 nm. Both loaded elastic and nonelastic niosomes showed good physical and chemical stability for 3 months. The percentages remaining of gallic acid in nonelastic were slightly higher than in elastic niosomes. Both elastic and nonelastic niosomes retarded rat skin permeation of the loaded pure gallic acid, while enhanced the loaded gallic acid in the semipurified fraction. However, elastic niosomes exhibited higher percentages of gallic acid through rat skin than the nonelastic niosomes.
This study has demonstrated the potential of niosomes, especially elastic niosomes, for the enhancement of chemical stability and rat skin transdermal absorption of gallic acid in the semipurified fraction from T. chebula galls, which will be beneficial for topical antiaging application.
研究从诃子（使君子科）叶状倍蚜虫瘿中分离得到的半纯化部位中载没食子酸的弹性类脂囊泡凝胶的透皮吸收增强作用。
制备载没食子酸的非弹性和弹性类脂囊泡，以及载没食子酸纯品或半纯化部位的载药类脂囊泡。通过垂直 Franz 扩散池，对载药弹性类脂囊泡凝胶或载药半纯化部位凝胶中各制剂的透皮吸收进行研究。
载没食子酸或半纯化部位的弹性和非弹性类脂囊泡均显示出单分子层和多分子层结构的混合物，具有负 ζ 电位值和 200-400nm 的粒径范围。载药弹性和非弹性类脂囊泡在 3 个月内均表现出良好的物理化学稳定性。非弹性类脂囊泡中没食子酸的残留率略高于弹性类脂囊泡。载药弹性和非弹性类脂囊泡均能延缓载药纯没食子酸的透皮渗透，同时增强载药半纯化部位中的没食子酸。然而，弹性类脂囊泡在大鼠皮肤中的透过率高于非弹性类脂囊泡。
本研究表明，类脂囊泡，特别是弹性类脂囊泡，具有增强没食子酸在 T. chebula 叶状倍蚜虫瘿半纯化部位中的化学稳定性和大鼠皮肤透皮吸收的潜力，这将有利于局部抗衰老应用。
