Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Ann Oncol. 2011 Aug;22(8):1910-5. doi: 10.1093/annonc/mdq672. Epub 2011 Feb 1.
Information on the relation between acrylamide exposure and risk of pancreatic cancer is scanty and inconsistent.
We investigated the issue in a case-control study conducted from 1991 to 2008 in Northern Italy. Cases were 326 patients with incident pancreatic cancer, admitted to major teaching and general hospitals. Controls were 652 subjects admitted to the same hospitals with acute non-neoplastic conditions. Acrylamide mean content of various food items was derived from international databases and Italian sources. Odds ratios (ORs) and 95% confidence intervals (CIs) of pancreatic cancer were derived using conditional logistic regression adjusted for several covariates, including energy intake.
The ORs of pancreatic cancer for subsequent quintiles of acrylamide intake, as compared with the lowest one, were 1.48 (95% CI 0.88-2.50), 1.57 (95% CI 0.91-2.69), 1.70 (95% CI 0.98-2.96) and 1.49 (95% CI 0.83-2.70), with no trend in risk (P value 0.21). The OR for an increase in acrylamide intake of 10 μg/day was 1.01 (95% CI 0.92-1.10). No meaningful difference between ORs was found in strata of smoking habit, alcohol drinking, body mass index and other selected covariates.
This study found no association between dietary acrylamide and pancreatic cancer in an Italian population.
丙烯酰胺暴露与胰腺癌风险之间的关系信息稀缺且不一致。
我们在 1991 年至 2008 年期间在意大利北部进行的一项病例对照研究中调查了这个问题。病例为 326 名新诊断为胰腺癌的患者，他们入住了主要教学医院和综合医院。对照组为 652 名因急性非肿瘤疾病入住同一医院的患者。各种食品中丙烯酰胺的平均含量源自国际数据库和意大利来源。使用条件逻辑回归，调整了能量摄入等几个协变量，得出了胰腺癌的比值比（ORs）和 95%置信区间（CIs）。
与最低丙烯酰胺摄入量相比，摄入丙烯酰胺的后续五分位数的胰腺癌 OR 分别为 1.48（95%CI 0.88-2.50）、1.57（95%CI 0.91-2.69）、1.70（95%CI 0.98-2.96）和 1.49（95%CI 0.83-2.70），风险无明显趋势（P 值为 0.21）。丙烯酰胺摄入量增加 10μg/天的 OR 为 1.01（95%CI 0.92-1.10）。在吸烟习惯、饮酒、体重指数和其他选定协变量的分层中，OR 之间没有明显差异。
本研究在意大利人群中未发现饮食丙烯酰胺与胰腺癌之间存在关联。
