Graduate School of Environmental Health, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Department of Food and Life Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Nutrients. 2020 Nov 22;12(11):3584. doi: 10.3390/nu12113584.
Acrylamide is a probable carcinogen in humans. Few studies have assessed dietary acrylamide intake and the risk of pancreatic cancer; however, these studies are based on Western populations. Our purpose was to investigate the association of dietary acrylamide intake with the risk of pancreatic cancer utilizing data from the Japan Public Health Center-based Prospective Study. We evaluated the data of 89,729 participants aged 45-74 years, who replied to a questionnaire on past medical history and lifestyle habits from 1995-1998. Dietary acrylamide intake was estimated utilizing a validated food frequency questionnaire. We calculated the hazard ratios and 95% confidence intervals by using Cox proportional-hazards regression models. The average follow-up was 15.2 years, and 576 cases of pancreatic cancer were diagnosed. In the multivariate-adjusted model, an association between dietary acrylamide intake and pancreatic cancer risk was not demonstrated (hazard ratio for the highest vs. lowest quartile = 0.83, 95% confidence interval: 0.65-1.05, for trend = 0.07). Furthermore, in the analyses stratified by sex, smoking status, coffee consumption, green tea consumption, alcohol consumption, and body mass index, no significant association was detected. Dietary acrylamide intake was not associated with the pancreatic cancer risk in Japanese individuals.
丙烯酰胺是一种可能的人类致癌物。少数研究评估了饮食中丙烯酰胺的摄入量与胰腺癌风险之间的关系；然而，这些研究基于西方人群。我们的目的是利用日本公共卫生中心前瞻性研究的数据，调查饮食中丙烯酰胺摄入量与胰腺癌风险之间的关联。我们评估了 1995-1998 年期间 89729 名年龄在 45-74 岁之间、回答过去病史和生活方式习惯问卷的参与者的数据。饮食中丙烯酰胺的摄入量是利用经过验证的食物频率问卷来估计的。我们使用 Cox 比例风险回归模型计算了风险比和 95%置信区间。平均随访时间为 15.2 年，诊断出 576 例胰腺癌病例。在多变量调整模型中，饮食中丙烯酰胺的摄入量与胰腺癌风险之间没有关联（最高与最低四分位数的风险比=0.83，95%置信区间：0.65-1.05，趋势=0.07）。此外，在按性别、吸烟状况、咖啡摄入量、绿茶摄入量、酒精摄入量和体重指数分层的分析中，未发现显著关联。在日本人群中，饮食中丙烯酰胺的摄入量与胰腺癌风险无关。
