University of California, San Francisco, CA, USA.
Sleep. 2011 Feb 1;34(2):171-9. doi: 10.1093/sleep/34.2.171.
To examine how self-reported ratings of sleep disturbance changed from the time of the simulation visit to four months after the completion of radiation therapy (RT) and to investigate whether specific patient, disease, and symptom characteristics predicted the initial levels of sleep disturbance and/or characteristics of the trajectories of sleep disturbance.
Prospective longitudinal study.
Two radiation therapy centers.
Patients (n = 82) who underwent primary or adjuvant RT for prostate cancer.
Changes in self-reported sleep disturbance were measured using the General Sleep Disturbance Scale (GSDS). Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression Scale. Trait and state anxiety were measured using the Spielberger State-Trait Anxiety Inventory. Hierarchical linear modeling was used to answer the study aims. Self-reported sleep disturbance increased during the course of RT and then decreased following the completion of RT. Predictors of higher levels of sleep disturbance included younger age, higher levels of trait anxiety, higher levels of depressive symptoms, and higher levels of sleep disturbance at the initiation of RT.
Sleep disturbance is a significant problem in patients with prostate cancer who undergo RT. Younger men with co-occurring depression and anxiety may be at greatest risk for sleep disturbance during RT.
探讨从模拟就诊到放疗结束后四个月，自我报告的睡眠障碍评分的变化情况，并研究特定的患者、疾病和症状特征是否预测了初始睡眠障碍水平和/或睡眠障碍轨迹的特征。
前瞻性纵向研究。
两个放射治疗中心。
接受前列腺癌原发或辅助放疗的患者（n=82）。
使用一般睡眠障碍量表（GSDS）测量自我报告的睡眠障碍变化。使用流行病学研究中心抑郁量表评估抑郁症状。使用斯皮尔伯格状态-特质焦虑量表测量特质和状态焦虑。采用分层线性模型回答研究目的。自我报告的睡眠障碍在放疗过程中增加，然后在放疗结束后下降。睡眠障碍水平较高的预测因素包括年龄较小、特质焦虑水平较高、抑郁症状水平较高以及放疗开始时睡眠障碍水平较高。
接受放疗的前列腺癌患者存在显著的睡眠障碍问题。同时患有抑郁和焦虑的年轻男性在放疗期间睡眠障碍的风险最大。
