School of Nursing, University of California, San Francisco, California 94143-0610, USA.
J Pain Symptom Manage. 2011 Aug;42(2):239-50. doi: 10.1016/j.jpainsymman.2010.11.010. Epub 2011 Mar 31.
Little is known about the occurrence and severity of sleep disturbance and fatigue between patients with common cancer diagnoses.
Study purposes were to evaluate for differences in the occurrence rates of sleep disturbances and fatigue; evaluate for differences in the severity of sleep disturbance using both subjective and objective measures; and evaluate for differences in the severity of self-reported fatigue in patients with breast and prostate cancer at the initiation of radiation therapy (RT).
Patients with breast (n=78) and prostate (n=82) cancer were evaluated before the initiation of RT using the Pittsburgh Sleep Quality Index, General Sleep Disturbance Scale, Lee Fatigue Scale, and wrist actigraphy. Differences in sleep disturbance and fatigue between groups were evaluated using independent sample t-tests and Chi-square analyses.
Occurrence rates for sleep disturbance (P<0.0001) and fatigue (P=0.03) were significantly higher in patients with breast compared with prostate cancer. Patients with breast cancer self-reported significantly higher levels of sleep disturbance (P=0.008) and fatigue (P=0.005) than patients with prostate cancer. However, using actigraphy, patients with prostate cancer had poorer sleep efficiency (P=0.02) than patients with breast cancer.
Based on self-report, patients with breast cancer experience sleep disturbance more frequently and with greater severity than patients with prostate cancer. Objective measures of sleep disturbance suggest that prostate cancer patients have more severe sleep disturbance than breast cancer patients. All the patients experienced poor sleep quality and fatigue, which suggests that oncology patients need to be assessed for these symptoms.
对于常见癌症诊断患者的睡眠障碍和疲劳的发生和严重程度知之甚少。
研究目的是评估睡眠障碍和疲劳的发生率差异；使用主观和客观措施评估睡眠障碍严重程度的差异；并评估在开始放射治疗（RT）时乳腺癌和前列腺癌患者自我报告的疲劳严重程度的差异。
使用匹兹堡睡眠质量指数、一般睡眠障碍量表、李疲劳量表和腕部活动记录仪，在开始 RT 之前评估乳腺癌（n=78）和前列腺癌（n=82）患者。使用独立样本 t 检验和卡方分析评估组间睡眠障碍和疲劳的差异。
与前列腺癌相比，乳腺癌患者的睡眠障碍（P<0.0001）和疲劳（P=0.03）发生率显著更高。乳腺癌患者自我报告的睡眠障碍（P=0.008）和疲劳（P=0.005）水平明显高于前列腺癌患者。然而，使用活动记录仪，前列腺癌患者的睡眠效率（P=0.02）比乳腺癌患者差。
基于自我报告，与前列腺癌患者相比，乳腺癌患者更频繁且更严重地经历睡眠障碍。睡眠障碍的客观测量表明，前列腺癌患者的睡眠障碍比乳腺癌患者更严重。所有患者的睡眠质量和疲劳都较差，这表明肿瘤患者需要评估这些症状。
