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利用非极性溶剂进行极性分析物的纸喷雾电离。

Paper spray ionization of polar analytes using non-polar solvents.

机构信息

Department of Chemistry and Center for Analytical Instrumentation Development, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA.

出版信息

Chem Commun (Camb). 2011 Mar 14;47(10):2811-3. doi: 10.1039/c0cc05513a. Epub 2011 Feb 1.

DOI:10.1039/c0cc05513a
PMID:21286639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3591489/
Abstract

Non-polar solvents like hexane allow ionization of insoluble drugs, peptides, nucleotides and phospholipids as solids from paper. Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper.

摘要

非极性溶剂，如己烷，可使不溶性药物、肽、核苷酸和磷脂在纸面上从固体状态下离子化。通过对湿润的纸张施加高压即可实现环境离子化。讨论了传输和离子化的机制，包括可能通过在纸张上形成的树枝状结构进行场解吸。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b63/3591489/cfd0bfe2c0f3/nihms379529f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b63/3591489/1ce11eb4a07d/nihms379529f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b63/3591489/cfd0bfe2c0f3/nihms379529f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b63/3591489/1ce11eb4a07d/nihms379529f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b63/3591489/cfd0bfe2c0f3/nihms379529f2.jpg

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