利用非极性溶剂进行极性分析物的纸喷雾电离。
Paper spray ionization of polar analytes using non-polar solvents.
机构信息
Department of Chemistry and Center for Analytical Instrumentation Development, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Chem Commun (Camb). 2011 Mar 14;47(10):2811-3. doi: 10.1039/c0cc05513a. Epub 2011 Feb 1.
Abstract
Non-polar solvents like hexane allow ionization of insoluble drugs, peptides, nucleotides and phospholipids as solids from paper. Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper.
摘要
非极性溶剂，如己烷，可使不溶性药物、肽、核苷酸和磷脂在纸面上从固体状态下离子化。通过对湿润的纸张施加高压即可实现环境离子化。讨论了传输和离子化的机制，包括可能通过在纸张上形成的树枝状结构进行场解吸。
相似文献
1
Paper spray ionization of polar analytes using non-polar solvents.利用非极性溶剂进行极性分析物的纸喷雾电离。
Chem Commun (Camb). 2011 Mar 14;47(10):2811-3. doi: 10.1039/c0cc05513a. Epub 2011 Feb 1.
2
Desorption and ionization mechanisms in desorption atmospheric pressure photoionization.解吸常压光电离中的解吸与电离机制。
Anal Chem. 2008 Oct 1;80(19):7460-6. doi: 10.1021/ac801186x. Epub 2008 Sep 6.
3
Detection of native proteins using solid-substrate electrospray ionization mass spectrometry with nonpolar solvents.使用非极性溶剂的固相电喷雾电离质谱法检测天然蛋白质。
Anal Chim Acta. 2018 Apr 3;1004:51-57. doi: 10.1016/j.aca.2017.11.079. Epub 2017 Dec 12.
4
In Situ Separation and Analysis of Lipids by Paper Spray Ionization Mass Spectrometry.纸喷雾电离质谱法原位分离和分析脂质。
Molecules. 2020 Dec 28;26(1):93. doi: 10.3390/molecules26010093.
5
Solvent jet desorption capillary photoionization-mass spectrometry.溶剂喷射解吸毛细管光电离质谱法
Anal Chem. 2015 Mar 17;87(6):3280-5. doi: 10.1021/ac504220v. Epub 2015 Mar 5.
6
Electroactive Polymer-Based Spray Ionization for Direct Mass Spectrometric Analysis.基于电活性聚合物的喷雾电离用于直接质谱分析。
J Am Soc Mass Spectrom. 2022 Oct 5;33(10):1840-1849. doi: 10.1021/jasms.2c00148. Epub 2022 Sep 23.
7
Desorption atmospheric pressure photoionization with polydimethylsiloxane as extraction phase and sample plate material.采用聚二甲基硅氧烷作为萃取相和样品板材料的解吸常压光电离。
Anal Chim Acta. 2010 Dec 3;682(1-2):1-8. doi: 10.1016/j.aca.2010.09.019. Epub 2010 Sep 22.
8
Analytical properties of electrospray ionization mass spectrometry with solid substrates and nonpolar solvents.电喷雾电离质谱分析与固体基质和非极性溶剂的特性。
Anal Chim Acta. 2019 Mar 7;1050:105-112. doi: 10.1016/j.aca.2018.10.064. Epub 2018 Oct 29.
9
Continuous flow-extractive desorption electrospray ionization: analysis from "non-electrospray ionization-friendly" solvents and related mechanism.连续流动-萃取解吸电喷雾电离：来自“非电喷雾电离友好型”溶剂的分析及相关机制。
Anal Chim Acta. 2013 Mar 26;769:84-90. doi: 10.1016/j.aca.2013.01.018. Epub 2013 Jan 20.
10
Paper spray-atmospheric pressure photoionization-high resolution mass spectrometry for the direct analysis of neutral fluorinated compounds in waterproof impregnation sprays.纸喷雾-大气压光电离-高分辨质谱法直接分析防水浸渍喷雾中的中性氟化化合物。
Anal Chim Acta. 2022 Apr 29;1204:339720. doi: 10.1016/j.aca.2022.339720. Epub 2022 Mar 12.
引用本文的文献
1
Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals.用于药物化学分析评估与合成制备的萃取电喷雾电离质谱法。
Front Pharmacol. 2023 Jan 13;14:1110900. doi: 10.3389/fphar.2023.1110900. eCollection 2023.
2
Multivariate classification techniques and mass spectrometry as a tool in the screening of patients with fibromyalgia.多元分类技术和质谱分析作为纤维肌痛患者筛选工具。
Sci Rep. 2021 Nov 19;11(1):22625. doi: 10.1038/s41598-021-02141-1.
3
In Situ Separation and Analysis of Lipids by Paper Spray Ionization Mass Spectrometry.纸喷雾电离质谱法原位分离和分析脂质。
Molecules. 2020 Dec 28;26(1):93. doi: 10.3390/molecules26010093.
4
Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications.纸喷雾质谱分析技术的新趋势：微采样、存储、直接分析及应用。
Mass Spectrom Rev. 2020 Jul;39(4):336-370. doi: 10.1002/mas.21601. Epub 2019 Sep 6.
5
Solvent-Assisted Paper Spray Ionization Mass Spectrometry (SAPSI-MS) for the Analysis of Biomolecules and Biofluids.溶剂辅助纸喷雾电离质谱（SAPSI-MS）用于生物分子和生物体液分析。
Sci Rep. 2019 Jul 16;9(1):10296. doi: 10.1038/s41598-019-45358-x.
6
Analysis of Compounds Dissolved in Nonpolar Solvents by Electrospray Ionization on Conductive Nanomaterials.基于导电纳米材料的电喷雾电离对溶解于非极性溶剂中的化合物进行分析。
J Am Soc Mass Spectrom. 2018 Mar;29(3):573-580. doi: 10.1007/s13361-017-1873-y. Epub 2018 Jan 25.
7
Ambient Ionization and Miniature Mass Spectrometry Systems for Disease Diagnosis and Therapeutic Monitoring.用于疾病诊断和治疗监测的常压电离与微型质谱系统
Theranostics. 2017 Jul 20;7(12):2968-2981. doi: 10.7150/thno.19410. eCollection 2017.
8
Clinical Application of Ambient Ionization Mass Spectrometry.常压电离质谱的临床应用
Mass Spectrom (Tokyo). 2017;6(Spec Iss):S0060. doi: 10.5702/massspectrometry.S0060. Epub 2017 Feb 24.
9
Electrospray Ionization on Solid Substrates.固体基质上的电喷雾电离
Mass Spectrom (Tokyo). 2014;3(Spec Issue):S0028. doi: 10.5702/massspectrometry.S0028. Epub 2014 May 1.
10
Analysis of polycyclic aromatic hydrocarbons using desorption atmospheric pressure chemical ionization coupled to a portable mass spectrometer.使用解吸常压化学电离与便携式质谱仪联用分析多环芳烃。
J Am Soc Mass Spectrom. 2015 Feb;26(2):271-80. doi: 10.1007/s13361-014-1029-2. Epub 2014 Dec 13.
本文引用的文献
1
Ultrasound ionization of biomolecules.超声生物分子电离。
Rapid Commun Mass Spectrom. 2010 Sep 15;24(17):2569-74. doi: 10.1002/rcm.4677.
2
Desorption electrospray ionization and other ambient ionization methods: current progress and preview.解吸电喷雾离子化和其他环境离子化方法：当前进展和展望。
Analyst. 2010 Apr;135(4):669-81. doi: 10.1039/b925257f. Epub 2010 Mar 2.
3
Ambient ionization mass spectrometry: current understanding of mechanistic theory; analytical performance and application areas.环境电离质谱：对机制理论的现有理解；分析性能和应用领域。
Analyst. 2010 Apr;135(4):661-8. doi: 10.1039/b925579f. Epub 2010 Mar 2.
4
Non-aqueous spray solvents and solubility effects in desorption electrospray ionization.非水喷雾溶剂和解离电喷雾中的溶解度效应。
J Am Soc Mass Spectrom. 2010 Apr;21(4):572-9. doi: 10.1016/j.jasms.2009.12.012. Epub 2010 Jan 4.
5
Paper spray for direct analysis of complex mixtures using mass spectrometry.用于质谱直接分析复杂混合物的纸喷雾技术。
Angew Chem Int Ed Engl. 2010;49(5):877-80. doi: 10.1002/anie.200906314.
6
Evolution of the solvent polarity in an electrospray plume.电喷雾羽流中溶剂极性的演变。
J Am Soc Mass Spectrom. 2010 Mar;21(3):378-85. doi: 10.1016/j.jasms.2009.10.022. Epub 2009 Nov 6.
7
Ambient analysis of saturated hydrocarbons using discharge-induced oxidation in desorption electrospray ionization.利用解吸电喷雾电离中的放电诱导氧化进行饱和烃的环境分析。
J Am Soc Mass Spectrom. 2010 Feb;21(2):261-7. doi: 10.1016/j.jasms.2009.10.006. Epub 2009 Nov 13.
8
What can we learn from ambient ionization techniques?我们能从环境电离技术中学到什么？
J Am Soc Mass Spectrom. 2009 Nov;20(11):1947-63. doi: 10.1016/j.jasms.2009.07.025. Epub 2009 Aug 13.
9
Generation of multiply charged peptides and proteins by radio frequency acoustic desorption and ionization for mass spectrometric detection.通过射频声解吸和电离产生多电荷肽和蛋白质用于质谱检测。
J Am Soc Mass Spectrom. 2009 Apr;20(4):597-600. doi: 10.1016/j.jasms.2008.11.024. Epub 2008 Dec 7.
10
Using electrospray-assisted laser desorption/ionization mass spectrometry to characterize organic compounds separated on thin-layer chromatography plates.使用电喷雾辅助激光解吸/电离质谱法对在薄层色谱板上分离的有机化合物进行表征。
Anal Chem. 2007 Nov 15;79(22):8789-95. doi: 10.1021/ac070590k. Epub 2007 Oct 12.
Zotero 插件