利用非极性溶剂进行极性分析物的纸喷雾电离。
Paper spray ionization of polar analytes using non-polar solvents.
机构信息
Department of Chemistry and Center for Analytical Instrumentation Development, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Chem Commun (Camb). 2011 Mar 14;47(10):2811-3. doi: 10.1039/c0cc05513a. Epub 2011 Feb 1.
Abstract
Non-polar solvents like hexane allow ionization of insoluble drugs, peptides, nucleotides and phospholipids as solids from paper. Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper.
摘要
非极性溶剂，如己烷，可使不溶性药物、肽、核苷酸和磷脂在纸面上从固体状态下离子化。通过对湿润的纸张施加高压即可实现环境离子化。讨论了传输和离子化的机制，包括可能通过在纸张上形成的树枝状结构进行场解吸。
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