常压电离质谱的临床应用
Clinical Application of Ambient Ionization Mass Spectrometry.
作者信息
Li Li-Hua, Hsieh Hua-Yi, Hsu Cheng-Chih
机构信息
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital.
Department of Chemistry, National Taiwan University.
出版信息
Mass Spectrom (Tokyo). 2017;6(Spec Iss):S0060. doi: 10.5702/massspectrometry.S0060. Epub 2017 Feb 24.
Abstract
Ambient ionization allows mass spectrometry analysis directly on the sample surface under atmospheric pressure with almost zero sample pretreatment. Since the development of desorption electrospray ionization (DESI) in 2004, many other ambient ionization techniques were developed. Due to their simplicity and low operation cost, rapid and on-site clinical mass spectrometry analysis becomes real. In this review, we will highlight some of the most widely used ambient ionization mass spectrometry approaches and their applications in clinical study.
摘要
常压电离允许在大气压下直接对样品表面进行质谱分析，且几乎无需样品预处理。自2004年解吸电喷雾电离（DESI）技术问世以来，又开发了许多其他常压电离技术。由于其操作简单、成本低，快速现场临床质谱分析成为现实。在本综述中，我们将重点介绍一些应用最广泛的常压电离质谱方法及其在临床研究中的应用。
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