• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Clinical Application of Ambient Ionization Mass Spectrometry.常压电离质谱的临床应用
Mass Spectrom (Tokyo). 2017;6(Spec Iss):S0060. doi: 10.5702/massspectrometry.S0060. Epub 2017 Feb 24.
2
Surface analysis of lipids by mass spectrometry: more than just imaging.质谱法分析脂质的表面特性：不止于成像。
Prog Lipid Res. 2013 Oct;52(4):329-53. doi: 10.1016/j.plipres.2013.04.005. Epub 2013 Apr 24.
3
[Detection of drugs in urine by ambient direct ionization mass spectrometry].[采用常压直接电离质谱法检测尿液中的药物]
Se Pu. 2022 Jul;40(7):677-683. doi: 10.3724/SP.J.1123.2022.01013.
4
Desorption electrospray ionization of explosives on surfaces: sensitivity and selectivity enhancement by reactive desorption electrospray ionization.表面爆炸物的解吸电喷雾电离：通过反应性解吸电喷雾电离提高灵敏度和选择性
Anal Chem. 2005 Nov 1;77(21):6755-64. doi: 10.1021/ac050995+.
5
Mass spectrometry imaging under ambient conditions.大气环境下的质谱成像。
Mass Spectrom Rev. 2013 May-Jun;32(3):218-43. doi: 10.1002/mas.21360. Epub 2012 Sep 20.
6
Comprehensive comparison of ambient mass spectrometry with desorption electrospray ionization and direct analysis in real time for direct sample analysis.环境质谱与解吸电喷雾电离和实时直接分析用于直接样品分析的综合比较。
Talanta. 2019 Oct 1;203:140-146. doi: 10.1016/j.talanta.2019.05.040. Epub 2019 May 11.
7
Update DESI Mass Spectrometry Imaging (MSI).更新解吸电喷雾电离质谱成像（DESI-MSI）。
Methods Mol Biol. 2023;2688:41-54. doi: 10.1007/978-1-0716-3319-9_4.
8
Analysis of lipids with desorption atmospheric pressure photoionization-mass spectrometry (DAPPI-MS) and desorption electrospray ionization-mass spectrometry (DESI-MS).采用解吸常压光电离质谱（DAPPI-MS）和解吸电喷雾电离质谱（DESI-MS）分析脂质。
J Mass Spectrom. 2012 May;47(5):611-9. doi: 10.1002/jms.2992.
9
Ambient Lipidomic Analysis of Single Mammalian Oocytes and Preimplantation Embryos Using Desorption Electrospray Ionization (DESI) Mass Spectrometry.使用解吸电喷雾电离（DESI）质谱法对单个哺乳动物卵母细胞和植入前胚胎进行环境脂质组学分析。
Methods Mol Biol. 2020;2064:159-179. doi: 10.1007/978-1-4939-9831-9_13.
10
Non-proximate detection of small and large molecules by desorption electrospray ionization and desorption atmospheric pressure chemical ionization mass spectrometry: instrumentation and applications in forensics, chemistry, and biology.通过解吸电喷雾电离和解吸大气压化学电离质谱法对小分子和大分子进行非近距离检测：仪器设备及其在法医学、化学和生物学中的应用
Anal Chem. 2007 Sep 15;79(18):7069-77. doi: 10.1021/ac0707939. Epub 2007 Aug 14.

引用本文的文献

1
Development and multicenter validation of on-site breast cancer diagnosis using paper spray ionization miniature mass spectrometry.基于纸喷雾电离微型质谱的现场乳腺癌诊断方法的开发与多中心验证
Commun Med (Lond). 2025 Jul 1;5(1):259. doi: 10.1038/s43856-025-00930-7.
2
Efficacy of Urine Asymmetric Dimethylarginine Concentration to Predict Azotemia in Hyperthyroid Cats After Radio-Iodine Treatment.尿不对称二甲基精氨酸浓度预测放射性碘治疗后甲状腺功能亢进猫氮质血症的疗效
J Vet Intern Med. 2025 May-Jun;39(3):e70096. doi: 10.1111/jvim.70096.
3
Untargeted Swab Touch Spray-Mass Spectrometry Analysis with Machine Learning for On-Site Breast Surgical Margin Assessment.基于机器学习的非靶向拭子接触喷雾质谱分析法用于现场乳腺手术切缘评估
Anal Chem. 2025 Feb 4;97(4):1960-1965. doi: 10.1021/acs.analchem.4c06062. Epub 2025 Jan 19.
4
Analysis of Pesticide Residues on Fruit Using Swab Spray Ionization Mass Spectrometry.涂抹喷雾离子化质谱法分析水果中的农药残留。
Molecules. 2023 Sep 14;28(18):6611. doi: 10.3390/molecules28186611.
5
Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin's Lymphoma.代谢组学：B细胞非霍奇金淋巴瘤诊断或预后的新时代。
Diagnostics (Basel). 2023 Feb 23;13(5):861. doi: 10.3390/diagnostics13050861.
6
Natural Product Discovery by Direct Analysis in Real Time Mass Spectrometry.通过实时质谱直接分析进行天然产物发现
Mass Spectrom (Tokyo). 2019;8(2):S0081. doi: 10.5702/massspectrometry.S0081. Epub 2020 Jan 11.
7
Empowering Clinical Diagnostics with Mass Spectrometry.质谱技术助力临床诊断
ACS Omega. 2020 Jan 30;5(5):2041-2048. doi: 10.1021/acsomega.9b03764. eCollection 2020 Feb 11.
8
Inline cartridge extraction for rapid brain tumor tissue identification by molecular profiling.通过分子分析进行INLINE 盒式提取，快速识别脑肿瘤组织。
Sci Rep. 2019 Dec 12;9(1):18960. doi: 10.1038/s41598-019-55597-7.
9
Applications of Mass Spectrometry for Clinical Diagnostics: The Influence of Turnaround Time.质谱在临床诊断中的应用：周转时间的影响。
Anal Chem. 2020 Jan 7;92(1):183-202. doi: 10.1021/acs.analchem.9b04901. Epub 2019 Nov 25.
10
Rapid Evaluation of Spermidine from 12 Bean Cultivars by Direct Real-Time Mass Spectrometry Analysis.12 种豆类作物中亚精胺的直接实时质谱分析快速评价。
Molecules. 2018 Aug 25;23(9):2138. doi: 10.3390/molecules23092138.

本文引用的文献

1
Ambient Ionization and FAIMS Mass Spectrometry for Enhanced Imaging of Multiply Charged Molecular Ions in Biological Tissues.环境电离和 FAIMS 质谱法增强生物组织中多电荷分子离子的成像。
Anal Chem. 2016 Dec 6;88(23):11533-11541. doi: 10.1021/acs.analchem.6b02798. Epub 2016 Nov 9.
2
Molecular Imaging of Growth, Metabolism, and Antibiotic Inhibition in Bacterial Colonies by Laser Ablation Electrospray Ionization Mass Spectrometry.利用激光烧蚀电喷雾电离质谱法对细菌菌落的生长、代谢和抗生素抑制进行分子成像。
Angew Chem Int Ed Engl. 2016 Nov 21;55(48):15035-15039. doi: 10.1002/anie.201607751. Epub 2016 Oct 4.
3
Shotgun Lipidomic Profiling of the NCI60 Cell Line Panel Using Rapid Evaporative Ionization Mass Spectrometry.采用快速蒸发离子化质谱技术对 NCI60 细胞系面板进行 shotgun 脂质组学分析。
Anal Chem. 2016 Aug 2;88(15):7507-14. doi: 10.1021/acs.analchem.6b00187. Epub 2016 Jul 15.
4
Hydrogel Micropatch and Mass Spectrometry-Assisted Screening for Psoriasis-Related Skin Metabolites.水凝胶微贴剂和质谱联用筛选银屑病相关皮肤代谢物。
Clin Chem. 2016 Aug;62(8):1120-8. doi: 10.1373/clinchem.2016.256396. Epub 2016 Jun 20.
5
Development and Application of Zirconia Coated Paper Substrate for High Sensitivity Analysis of Therapeutic Drugs in Dried Blood Spots.用于干血斑中治疗药物高灵敏度分析的氧化锆涂层纸基质的开发与应用。
Anal Chem. 2016 Jul 19;88(14):7005-13. doi: 10.1021/acs.analchem.5b04732. Epub 2016 Jun 28.
6
LESA FAIMS Mass Spectrometry for the Spatial Profiling of Proteins from Tissue.LESA FAIMS 质谱法用于组织中蛋白质的空间分析。
Anal Chem. 2016 Jul 5;88(13):6758-66. doi: 10.1021/acs.analchem.6b01060. Epub 2016 Jun 14.
7
Rapid point-of-care identification of oral medications in gastric lavage content by ambient mass spectrometry in the emergency room.急诊室中通过常压质谱法对洗胃内容物中的口服药物进行快速即时检测。
Rapid Commun Mass Spectrom. 2016 Jun 15;30(11):1295-303. doi: 10.1002/rcm.7557.
8
Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry.通过解吸电喷雾电离质谱法对大脑中的多种神经递质和神经活性物质进行同步成像。
Neuroimage. 2016 Aug 1;136:129-38. doi: 10.1016/j.neuroimage.2016.05.004. Epub 2016 May 4.
9
Ambient ionization based on mesoporous graphene coated paper for therapeutic drug monitoring.基于介孔石墨烯包覆纸的常压电离用于治疗药物监测。
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:142-149. doi: 10.1016/j.jchromb.2016.01.040. Epub 2016 Jan 28.
10
Rapid identification of pesticides in human oral fluid for emergency management by thermal desorption electrospray ionization/mass spectrometry.热脱附电喷雾电离/质谱法快速鉴定人唾液中的农药用于应急处理
J Mass Spectrom. 2016 Feb;51(2):97-104. doi: 10.1002/jms.3719.

常压电离质谱的临床应用

Clinical Application of Ambient Ionization Mass Spectrometry.

作者信息

Li Li-Hua, Hsieh Hua-Yi, Hsu Cheng-Chih

机构信息

Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital.

Department of Chemistry, National Taiwan University.

出版信息

Mass Spectrom (Tokyo). 2017;6(Spec Iss):S0060. doi: 10.5702/massspectrometry.S0060. Epub 2017 Feb 24.

DOI:10.5702/massspectrometry.S0060
PMID:28337399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5359754/
Abstract

Ambient ionization allows mass spectrometry analysis directly on the sample surface under atmospheric pressure with almost zero sample pretreatment. Since the development of desorption electrospray ionization (DESI) in 2004, many other ambient ionization techniques were developed. Due to their simplicity and low operation cost, rapid and on-site clinical mass spectrometry analysis becomes real. In this review, we will highlight some of the most widely used ambient ionization mass spectrometry approaches and their applications in clinical study.

摘要

常压电离允许在大气压下直接对样品表面进行质谱分析，且几乎无需样品预处理。自2004年解吸电喷雾电离（DESI）技术问世以来，又开发了许多其他常压电离技术。由于其操作简单、成本低，快速现场临床质谱分析成为现实。在本综述中，我们将重点介绍一些应用最广泛的常压电离质谱方法及其在临床研究中的应用。