Anselme K, Ponche A, Bigerelle M
Institut de Sciences des Matériaux de Mulhouse (IS2M), CNRS LRC7228, Université de Haute-Alsace, Mulhouse, France.
Proc Inst Mech Eng H. 2010 Dec;224(12):1487-507. doi: 10.1243/09544119JEIM901.
A current medical challenge is the replacement of tissue which can be thought of in terms of bone tissue engineering approaches. The key problem in bone tissue engineering lies in associating bone stem cells with material supports or scaffolds that can be implanted in a patient. Beside bone tissue engineering approaches, these types of materials are used daily in orthopaedics and dental practice as permanent or transitory implants such as ceramic bone filling materials or metallic prostheses. Consequently, it is essential to better understand how bone cells interact with materials. For several years, the current authors and others have developed in vitro studies in order to elucidate the mechanisms underlying the response of human bone cells to implant surfaces. This paper reviews the current state of knowledge and proposes future directions for research in this domain.
当前的医学挑战之一是组织替换，这可以从骨组织工程方法的角度来考虑。骨组织工程的关键问题在于将骨干细胞与可植入患者体内的材料支架相结合。除了骨组织工程方法外，这类材料在骨科和牙科实践中每天都被用作永久性或临时性植入物，如陶瓷骨填充材料或金属假体。因此，更好地了解骨细胞与材料之间的相互作用至关重要。多年来，本文作者及其他研究人员开展了体外研究，以阐明人类骨细胞对植入物表面反应的潜在机制。本文综述了该领域的现有知识状况，并提出了未来的研究方向。
