Ponche A, Bigerelle M, Anselme K
Institut de Sciences des Matériaux de Mulhouse (IS2M), CNRS LRC7228, Université de Haute-Alsace, Mulhouse, France.
Proc Inst Mech Eng H. 2010 Dec;224(12):1471-86. doi: 10.1243/09544119JEIM900.
Knowledge of the complexity of cell-material interactions is essential for the future of biomaterials and tissue engineering, but we are still far from achieving a clear understanding, as illustrated in this review. Many factors of the cellular or the material aspect influence these interactions and must be controlled systematically during experiments. On the material side, it is essential to illustrate surface topography by parameters describing the roughness amplitude as well as the roughness organization, and at the scales pertinent for the cell response, i.e., from the nano-scale to the micro-scale. Authors interested in this field must be careful to develop surfaces or methods systematically, allowing perfect control of the relative influences of surface topography and surface chemistry.
了解细胞与材料相互作用的复杂性对于生物材料和组织工程的未来至关重要，但正如本综述所示，我们仍远未达成清晰的认识。细胞或材料方面的许多因素都会影响这些相互作用，在实验过程中必须对其进行系统控制。在材料方面，通过描述粗糙度幅度以及粗糙度组织的参数，并在与细胞反应相关的尺度上（即从纳米尺度到微米尺度）来说明表面形貌至关重要。该领域的作者在系统开发表面或方法时必须谨慎，以便能够完美控制表面形貌和表面化学的相对影响。
