内皮细胞中瞬时受体电位通道的氧化还原调节
Redox regulation of transient receptor potential channels in the endothelium.
作者信息
Pires Paulo Wagner, Earley Scott
机构信息
Department of Pharmacology, Cardiovascular Research Center, Reno School of Medicine, University of Nevada, Reno, NV, USA.
出版信息
Microcirculation. 2017 Apr;24(3). doi: 10.1111/micc.12329.
Abstract
ROS and RNS are important mediators of signaling pathways in the endothelium. Specific members of the TRP superfamily of cation channels act as important Ca influx pathways in endothelial cells and are involved in endothelium-dependent vasodilation, regulation of barrier permeability, and angiogenesis. ROS and RNS can modulate the activity of certain TRP channels mainly by modifying specific cysteine residues or by stimulating the production of second messengers. In this review, we highlight the recent literature describing redox regulation of TRP channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases.
摘要
活性氧（ROS）和活性氮（RNS）是内皮细胞信号通路的重要介质。瞬时受体电位（TRP）超家族阳离子通道的特定成员在内皮细胞中作为重要的钙内流途径，参与内皮依赖性血管舒张、屏障通透性调节和血管生成。ROS和RNS主要通过修饰特定的半胱氨酸残基或刺激第二信使的产生来调节某些TRP通道的活性。在这篇综述中，我们重点介绍了描述内皮细胞中TRP通道活性氧化还原调节的最新文献，以及这些途径的生理重要性及其对心血管疾病的影响。
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