Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Chemistry. 2011 Mar 1;17(10):2981-6. doi: 10.1002/chem.201002093. Epub 2011 Feb 2.
Herein, a new copper-catalysed strategy for the synthesis of rare nitrogen-linked seven-, eight- and nine-membered biaryl ring systems is described. It is proposed that the reaction proceeds through a highly activated intramolecularly co-ordinated copper catalyst. The process is technically simple, proceeds under relatively mild conditions, displays a broad substrate scope and forms biologically valuable products that are difficult to synthesise by other methods. We envisage that this methodology will prove useful in a wide synthetic context, with possible applications in both target-oriented and diversity-oriented synthesis.
本文描述了一种新的铜催化策略，用于合成罕见的氮连接的七元、八元和九元联芳环系统。据推测，反应是通过高度活化的分子内配位铜催化剂进行的。该过程技术简单，在相对温和的条件下进行，具有广泛的底物范围，并形成了通过其他方法难以合成的具有生物价值的产物。我们预计这种方法将在广泛的合成背景下证明是有用的，可能在目标导向和多样性导向合成中都有应用。
