The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, Qld 4072, Australia.
Curr Drug Deliv. 2011 May;8(3):282-9. doi: 10.2174/156720111795256192.
Classical vaccines incorporating live or attenuated microorganisms possess several disadvantages and cannot be applied against cancer and some pathogens. Modern vaccines utilizing immunogenic subunits derived from a particular pathogen are able to overcome these obstacles but need a specific delivery system for their efficacy. Nanotechnology has opened a new window into these delivery methodologies. A nano-sized formulation of subunit vaccines has been proven to be very effective in inducing cellular and humoral immune responses. Here, we review a number of peptide vaccine delivery strategies based on nanoparticles composed of polymers, peptides, lipids, and inorganic materials.
经典疫苗采用活的或减毒的微生物，具有若干缺点，不能用于预防癌症和某些病原体。利用特定病原体的免疫原性亚单位的现代疫苗能够克服这些障碍，但需要特定的传递系统才能发挥效力。纳米技术为这些传递方法开辟了新的窗口。亚单位疫苗的纳米制剂已被证明能非常有效地诱导细胞和体液免疫反应。在此，我们综述了基于聚合物、肽、脂类和无机材料的纳米颗粒的若干肽疫苗传递策略。
