Health Protection Agency Centre for Infections, 61 Colindale Avenue, UK.
Vaccine. 2011 Mar 21;29(14):2613-8. doi: 10.1016/j.vaccine.2011.01.046. Epub 2011 Feb 1.
This study reports effectiveness of trivalent influenza vaccine (TIV) against confirmed pandemic influenza infection in England using a retrospective test-negative case-control study. Cases and controls were frequency matched by age, swabbing-week and region. On univariable and multivariable analysis adjusted for underlying clinical risk factors, cases were no more or less likely than controls to be vaccinated with 2008-09 or 2007-08 season TIV. Adjusted vaccine effectiveness for the former was -6% (-43% to 22%). Vaccine effectiveness did not differ significantly by age-group or hospitalisation status. There was no evidence prior vaccination with TIV significantly altered subsequent risk of pandemic influenza H1N1 2009 infection.
本研究使用回顾性病例对照研究报告了三价流感疫苗（TIV）在英格兰预防确诊大流行性流感感染的效果。病例和对照按年龄、采样周和地区进行频率匹配。在调整了潜在临床危险因素的单变量和多变量分析中，病例组和对照组接种 2008-09 或 2007-08 季节 TIV 的可能性没有更多或更少。前者的调整疫苗有效性为-6%（-43%至 22%）。疫苗有效性在年龄组或住院状态之间没有显著差异。没有证据表明先前接种 TIV 会显著改变随后感染 2009 年大流行性流感 H1N1 的风险。
