Ciuffetti G, Mannarino E, Mercuri M, Pasqualini L, Lombardini R, Ott C, Santambrogio L
2nd Department of Internal Medicine, University of Perugia, Italy.
Int Angiol. 1990 Oct-Dec;9(4):246-50.
Before and after a physical training programme a treadmill exercise was used to stress leg circulation and induce ischaemia in 20 patients affected by peripheral arterial occlusive disease (PAOD). Transcutaneous oxygen pressure (TcPO2) was monitored constantly and blood samples drawn at baseline, the onset of calf pain, the maximum walking time, the minimum TcPO2 value, and when the TcPO2 recovered half its basal value. The mononuclear and polymorphonuclear leucocyte subfractions were separated by density and their filterability rates (through 5 microns pore diameter Nuclepore filters) measured using a positive pressure filtration system. The mononuclear filterability rate was significantly impaired throughout the ischaemic event and inversely correlated with the TcPO2 values. Physical training while delaying the onset and progress of ischaemia did not modify this pattern, implying that regular exercise does not affect the rheological properties of leukocytes--impairments in which are markers of ischaemia.
在一项体育训练计划前后，对20名患有外周动脉闭塞性疾病（PAOD）的患者使用跑步机运动来加重腿部血液循环并诱发缺血。持续监测经皮氧分压（TcPO2），并在基线、小腿疼痛发作时、最长步行时间、最低TcPO2值以及TcPO2恢复到其基础值的一半时采集血样。通过密度分离单核细胞和多形核白细胞亚群，并使用正压过滤系统测量它们的过滤率（通过5微米孔径的核孔过滤器）。在整个缺血事件中，单核细胞过滤率显著受损，并且与TcPO2值呈负相关。体育训练虽然延迟了缺血的发作和进展，但并未改变这种模式，这意味着规律运动不会影响白细胞的流变学特性——白细胞流变学特性受损是缺血的标志。
