Ciuffetti G, Ott C, Mercuri M, Lombardini R, Lupattelli G, Mannarino E
2. Klinik für Innere Medizin, Universität Perugia, Italien.
Z Gerontol. 1990 Nov-Dec;23(6):361-4.
Transcutaneous oxygen pressure (tcPO2), the unfractionated leukocyte filterability rate (ULFR), and plasma oxydant activity (POA) were monitored during a standard treadmill exercise test (2 km/h, 12 degrees slope) in two groups of stage-II peripheral vascular disease patients: one middle-aged group with an average age of 55 +/- 3 s.d. years, the other group elderly (average age 68 +/- 4 s.d. years). The results were compared to a healthy control group of 20 volunteers (average age 52 +/- 4 s.d. years). At the maximum walking time, the ULFR was significantly (p less than 0.001) impaired in both groups of patients compared to controls, and the level of plasma oxidant activity increased significantly (p less than 0.001). When the tcPO2 recovered half its basal value, the level of plasma oxidant activity approached basal values but the ULFR remained significantly (p less than 0.001) impaired. Inter-group analysis showed the total walking time was significantly (p less than 0.05) shorter in the elderly patients, and at the tcPO2 half recovery time the ULFR was significantly (p less than 0.01) more impaired.
在标准跑步机运动试验（2公里/小时，12度坡度）期间，对两组II期外周血管疾病患者的经皮氧分压（tcPO2）、未分级白细胞滤过率（ULFR）和血浆氧化活性（POA）进行了监测：一组为中年组，平均年龄55±3标准差岁，另一组为老年组（平均年龄68±4标准差岁）。将结果与20名志愿者组成的健康对照组（平均年龄52±4标准差岁）进行比较。在最大行走时间时，与对照组相比，两组患者的ULFR均显著受损（p<0.001），血浆氧化活性水平显著升高（p<0.001）。当tcPO2恢复到其基础值的一半时，血浆氧化活性水平接近基础值，但ULFR仍显著受损（p<0.001）。组间分析显示，老年患者的总行走时间显著缩短（p<0.05），在tcPO2恢复一半时间时，ULFR受损更显著（p<0.01）。
