Ciuffetti G, Mannarino E, Mercuri M, Pasqualini L, Lombardini R, Ott C, Lupattelli G, Paltriccia R
2nd Department of Internal Medicine, University of Perugia, Italy.
Vasa. 1990;19(3):234-6.
Plasma oxidant activity (marker of reactive oxygen metabolites) and the unfractionated leucocyte filterability rate (determined through 5 micron pore diameter Nuclepore filters, using a positive pressure system) were monitored in 15 stage II peripheral vascular disease (PVD) patients before and after ischaemia was induced by treadmill exercise (12 degrees slope/2 km/hour). Plasma oxidant activity increased (+ 115%) significantly (p less than 0.001) at the maximum walking time, correlating (r = 0.79) with a significant (p less than 0.001) impairment (+23%) in the unfractionated leucocyte filterability rate. At the transcutaneous oxygen pressure (tcPO2) half recovery time the plasma oxidant activity approached basal values but the unfractionated leucocyte filterability rate remained significantly (p less than 0.001) impaired (+16%). It returned to basal values at the full tcPO2 recovery time. These results show reactive oxygen metabolites are released during ischaemia of the lower limbs and are correlated with a significant impairment in the flow properties of leucocytes.
在15名II期外周血管疾病（PVD）患者中，通过跑步机运动（坡度12度/速度2公里/小时）诱导缺血前后，监测血浆氧化活性（活性氧代谢产物标志物）和全血白细胞滤过率（使用正压系统，通过5微米孔径的核孔滤膜测定）。在最大步行时间时，血浆氧化活性显著增加（+115%）（p<0.001），与全血白细胞滤过率显著（p<0.001）降低（-23%）相关（r = 0.79）。在经皮氧分压（tcPO2）恢复到一半时间时，血浆氧化活性接近基础值，但全血白细胞滤过率仍显著（p<0.001）降低（-16%）。在tcPO2完全恢复时，其恢复到基础值。这些结果表明，下肢缺血期间会释放活性氧代谢产物，并且与白细胞流动特性的显著降低相关。
