Department of Ophthalmology and Vision Science, Davis Eye Center, University of California, Davis, CA, USA.
Eye (Lond). 2011 Mar;25(3):279-89. doi: 10.1038/eye.2010.218. Epub 2011 Feb 4.
Inner and outer retinal morphology were quantified in vivo for 6 nonglaucomatous and 10 glaucomatous optic neuropathy patients. Custom, ultrahigh-resolution imaging modalities were used to evaluate segmented retinal layer thickness in 3D volumes (Fourier-domain optical coherence tomography), cone photoreceptor density (adaptive optics fundus camera), and the length of inner and outer segments of cone photoreceptors (adaptive optics-optical coherence tomography). Quantitative comparisons were made with age-matched controls, or by comparing affected and nonaffected retinal areas defined by changes in visual fields. The integrity of outer retinal layers on optical coherence tomography B-scans and density of cone photoreceptors were correlated with visual field sensitivity at corresponding retinal locations following reductions in inner retinal thickness. The photoreceptor outer segments were shorter and exhibited greater variability in retinal areas associated with visual field losses compared with normal or less affected areas of the same patient's visual field. These results demonstrate that nonglaucomatous and glaucomatous optic neuropathies are associated with outer retinal changes following long-term inner retinal pathology.
对 6 名非青光眼性视神经病变患者和 10 名青光眼性视神经病变患者进行了活体内外视网膜形态学定量研究。采用定制的超高分辨率成像方式，在 3D 容积（频域光学相干断层扫描）中评估视网膜分层厚度、圆锥状光感受器密度（自适应光学眼底相机）以及圆锥状光感受器内外节的长度（自适应光学-光学相干断层扫描）。与年龄匹配的对照组进行定量比较，或通过比较视野变化定义的受影响和不受影响的视网膜区域进行比较。在视神经病变患者中，随着内视网膜厚度的减少，光学相干断层扫描 B 扫描中外层视网膜的完整性和圆锥状光感受器的密度与相应视网膜位置的视野敏感性相关。与正常或受影响较小的视野区域相比，与视野丧失相关的视网膜区域的光感受器外节更短，且表现出更大的可变性。这些结果表明，非青光眼性和青光眼性视神经病变与长期内视网膜病变后外视网膜变化有关。
