Exner T, McRea J
Haematology Department, Westmead Hospital, Sydney, NSW.
Blood Coagul Fibrinolysis. 1990 Mar-Apr;1(1):17-21. doi: 10.1097/00001721-199003000-00004.
The correlation between lupus anticoagulant (LA) potency and anticardiolipin antibody (ACA) ELISA was found to be poor (r = 0.40) in a group of 56 patients accumulated by a haematology department mainly for studies of LA. This correlation was similar whether LAs were assessed by kaolin clotting time or activated partial thromboplastin time increments. When the more procoagulant phospholipid phosphatidyl serine, used in a calcium-containing buffer, was substituted for cardiolipin in the ELISA, the correlation with LA was only slightly improved (r = 0.58). In fact, binding of antibody from patient plasmas to blank wells, although quantitatively reduced, was found to correlate equally well with LA activity. LAs are not necessarily phospholipid-binding antibodies but may interfere more generally with other surface-dependent processes in the clotting mechanism.
在一个主要由血液科积累的、用于狼疮抗凝物质（LA）研究的56例患者组中，发现狼疮抗凝物质（LA）效价与抗心磷脂抗体（ACA）酶联免疫吸附测定（ELISA）之间的相关性较差（r = 0.40）。无论LA是通过高岭土凝血时间还是活化部分凝血活酶时间增加值来评估，这种相关性都是相似的。当在ELISA中，将用于含钙缓冲液中的促凝磷脂磷脂酰丝氨酸替代心磷脂时，与LA的相关性仅略有改善（r = 0.58）。事实上，发现患者血浆中的抗体与空白孔的结合，虽然在数量上减少了，但与LA活性的相关性同样良好。LA不一定是磷脂结合抗体，而可能更普遍地干扰凝血机制中其他依赖表面的过程。
