Department of Pharmacology & Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, and Hospital of Venereal & Skin Diseases of Thessaloniki, Thessaloniki, Greece.
J Eur Acad Dermatol Venereol. 2011 Mar;25(3):345-53. doi: 10.1111/j.1468-3083.2010.03796.x.
External anogenital warts (EGWs) are non-malignant skin tumours caused by human papillomavirus. They are one of the fastest growing sexually transmitted diseases. Current treatments are unsatisfactory. Green tea sinecatechin Polyphenon E ointment is a botanical extract from green tea leaves exhibiting anti-oxidant, anti-viral and anti-tumour properties.
The aim of this study was to integrate valid information and provide basis for rational decision making regarding efficacy and safety of green tea extracts in the treatment of EGWs.
A systematic search in electronic databases was conducted using specific key terms. Main search was performed independently by two reviewers. The accumulated relevant literature was subsequently systematically reviewed and a meta-analysis was conducted.
Three randomized, double-blind, placebo-controlled studies evaluating efficacy and safety of Polyphenon E 15% and 10% in the treatment of warts were included in the systematic review and meta-analysis. A total of 660 men and 587 women were enrolled. Regarding primary outcome, both Polyphenon E 15% and 10% demonstrated significantly higher likelihood of complete clearance of baseline and baseline and new warts compared with controls. No significant heterogeneity was detected. Recurrence rates were very low. Commonest local skin sign was erythema and local skin symptom was itching.
Efficacy of Polyphenon 15% and 10%, at least for the primary endpoint, is clearly indicated. Polyphenon E treatment exhibits very low recurrence rates and appears to have a rather favourable safety and tolerability profile. Recommendations for future studies should include evaluation of the efficacy of green tea catechins in the treatment of internal anogenital warts and direct comparison with its principal comparator, imiquimod.
外阴生殖器疣（EGWs）是由人乳头瘤病毒引起的非恶性皮肤肿瘤。它们是增长最快的性传播疾病之一。目前的治疗方法并不令人满意。绿茶儿茶素多酚 E 软膏是一种从绿茶叶中提取的植物提取物，具有抗氧化、抗病毒和抗肿瘤特性。
本研究旨在整合有效信息，为绿茶提取物治疗 EGWs 的疗效和安全性提供合理决策的依据。
使用特定的关键词在电子数据库中进行系统搜索。主要搜索由两名评审员独立进行。随后对累积的相关文献进行系统综述和荟萃分析。
纳入了三项随机、双盲、安慰剂对照研究，评估了多酚 E 15%和 10%治疗疣的疗效和安全性。共有 660 名男性和 587 名女性入组。关于主要结局，多酚 E 15%和 10%与对照组相比，基线和新疣的完全清除率明显更高。未检测到显著异质性。复发率非常低。最常见的局部皮肤征象是红斑，局部皮肤症状是瘙痒。
多酚 E 15%和 10%的疗效（至少对主要终点而言）是明确的。多酚 E 治疗的复发率非常低，且具有良好的安全性和耐受性。对未来研究的建议应包括评估绿茶儿茶素治疗内生殖器疣的疗效，并与主要对照药咪喹莫特进行直接比较。
