Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Nutrients. 2022 Jul 30;14(15):3149. doi: 10.3390/nu14153149.
Green-tea-based products and their polyphenols, especially epigallocatechin-3-gallate, have attracted great attention over the years as possible nutraceuticals, due to their promising bioactivities, especially antioxidant and anti-inflammatory, which could be exploited in several diseases, including skin ailments. In this context, the present study aimed at reviewing clinical evidence about the benefits of the oral administration of green tea preparations and its polyphenols to relieve skin disorders, to point out the current knowledge, and to suggest possible novel strategies to effectively exploit the properties of green tea, also managing safety risks. To this end, a systematic review of the existing literature was carried out, using the PRISMA method. Few studies, including five focused on UV-induced erythema and skin alterations, three on photoaging, two on antioxidant skin defenses, and one on acne and genodermatosis, were retrieved. Despite several benefits, clinical evidence only supports the use of oral green tea preparations to protect skin from damage induced by ultraviolet radiation; in other cases, conflicting results and methodological limits of clinical trials do not allow one to clarify their efficacy. Therefore, their application as adjuvant or alternative sunscreen-protective interventions could be encouraged, in compliance with the safety recommendations.
多年来，基于绿茶的产品及其多酚，特别是表没食子儿茶素没食子酸酯，因其具有有前景的生物活性而备受关注，尤其是抗氧化和抗炎作用，这可能对包括皮肤疾病在内的多种疾病有治疗作用。在此背景下，本研究旨在综述口服绿茶制剂及其多酚缓解皮肤疾病的临床证据，指出当前的知识，并提出可能的新策略，以有效利用绿茶的特性，同时管理安全风险。为此，我们采用 PRISMA 方法对现有文献进行了系统综述。仅检索到少数研究，其中 5 项集中于紫外线诱导的红斑和皮肤改变，3 项研究光老化，2 项研究抗氧化皮肤防御，1 项研究痤疮和遗传性皮肤病。尽管有多种益处，但临床证据仅支持使用口服绿茶制剂来保护皮肤免受紫外线辐射造成的损伤；在其他情况下，临床试验的结果相互矛盾且存在方法学限制，无法明确其疗效。因此，为了符合安全建议，可以鼓励将其作为辅助或替代防晒保护干预措施应用。
