Centre for Sport and Exercise Science, Sheffield Hallam University, UK.
Microvasc Res. 2011 May;81(3):331-6. doi: 10.1016/j.mvr.2011.01.008. Epub 2011 Feb 3.
Microvascular integrity is compromised by several diseases and conditions as well as age. Exercise can reverse these effects but it is unclear whether these are systemic or localised, or which mechanisms are responsible for observed improvements Therefore, the primary objective of this study was to assess whether arm-cranking exercise had a systemic or localised cutaneous, microcirculatory effect in an older, healthy population and compare these findings with our previous work on patients with chronic venous disease. A secondary objective was to see if improvements were greater in the lower- or in the upper-limb.
Endothelial-dependent- and independent-vasodilation were assessed on the forearm and the perimalleolar region in 14 older (59±4.5years), sedentary, healthy participants using LDF and incremental doses of acetylcholine (ACh) and sodium nitroprusside (SNP), before and after a session of arm-cranking exercise. Cutaneous blood flux data were expressed as cutaneous vascular conductance (CVC).
Endothelial-dependent vasodilation increased both in the upper- (p=0.04, d=0.59) and lower-limb (p=0.03, d=0.52), after exercise. Endothelial-independent vasodilation did not change either in the lower- and upper-limb (p>0.05 on both occasions). "Between-limbs" comparison showed that pre-exercise differences between the forearm and the lower-leg (p=0.04, d=0.47) disappeared after ACh-induced vasodilation, following arm-cranking exercise (p>0.05). Conversely, SNP-induced did not change.
Our results suggest that in a healthy, sedentary population (and in contrast to post-surgical varicose vein patients), acute arm-cranking exercise leads to an improvement of microvascular endothelial function in the extremities.
微血管完整性受到多种疾病和状况以及年龄的影响。运动可以逆转这些影响，但尚不清楚这些影响是全身性的还是局部性的，或者哪些机制负责观察到的改善。因此，本研究的主要目的是评估手臂旋转运动对老年健康人群是否具有全身性或局部皮肤、微血管效应，并将这些发现与我们之前对慢性静脉疾病患者的研究进行比较。次要目的是观察改善是否在上肢或下肢更为明显。
使用 LDF 和乙酰胆碱（ACh）和硝普钠（SNP）的递增剂量，在 14 名久坐、健康的老年（59±4.5 岁）参与者的前臂和小腿外周区域评估内皮依赖性和非依赖性血管舒张。皮肤血流数据表示为皮肤血管传导率（CVC）。
运动后，上肢（p=0.04，d=0.59）和下肢（p=0.03，d=0.52）的内皮依赖性血管舒张均增加。下肢和上肢的内皮非依赖性血管舒张均无变化（两次均 p>0.05）。“四肢之间”的比较表明，手臂旋转运动后，ACh 诱导的血管舒张后，前臂和小腿之间的预运动差异（p=0.04，d=0.47）消失（p>0.05）。相反，SNP 诱导的没有变化。
我们的结果表明，在健康的久坐人群中（与手术后静脉曲张患者相反），急性手臂旋转运动可改善四肢的微血管内皮功能。
