Institute of Physical Chemistry, University of Zurich, Switzerland.
Adv Colloid Interface Sci. 2011 Feb 17;162(1-2):87-106. doi: 10.1016/j.cis.2010.12.007. Epub 2011 Jan 12.
Protein adsorption at solid surfaces plays a key role in many natural processes and has therefore promoted a widespread interest in many research areas. Despite considerable progress in this field there are still widely differing and even contradictive opinions on how to explain the frequently observed phenomena such as structural rearrangements, cooperative adsorption, overshooting adsorption kinetics, or protein aggregation. In this review recent achievements and new perspectives on protein adsorption processes are comprehensively discussed. The main focus is put on commonly postulated mechanistic aspects and their translation into mathematical concepts and model descriptions. Relevant experimental and computational strategies to practically approach the field of protein adsorption mechanisms and their impact on current successes are outlined.
蛋白质在固体表面的吸附在许多自然过程中起着关键作用，因此在许多研究领域引起了广泛的关注。尽管在这一领域取得了相当大的进展，但对于如何解释经常观察到的现象，如结构重排、协同吸附、过冲吸附动力学或蛋白质聚集，仍然存在广泛的分歧，甚至相互矛盾的观点。在这篇综述中，全面讨论了蛋白质吸附过程的最新成果和新视角。主要重点放在普遍假定的机制方面及其转化为数学概念和模型描述上。概述了相关的实验和计算策略，以实际接近蛋白质吸附机制领域及其对当前成功的影响。
