细胞自主生物钟对脂肪酸代谢的调节：是时候从信息中获取营养了？
Regulation of fatty acid metabolism by cell autonomous circadian clocks: time to fatten up on information?
机构信息
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
出版信息
J Biol Chem. 2011 Apr 8;286(14):11883-9. doi: 10.1074/jbc.R110.214643. Epub 2011 Feb 4.
Abstract
Molecular, cellular, and animal-based studies have recently exposed circadian clocks as critical regulators of energy balance. Invariably, mouse models of genetically manipulated circadian clock components display features indicative of altered lipid/fatty acid metabolism, including differential adiposity and circulating lipids. The purpose of this minireview is to provide a comprehensive summary of current knowledge regarding the regulation of fatty acid metabolism by distinct cell autonomous circadian clocks. The implications of these recent findings for cardiometabolic disease and human health are discussed.
摘要
分子、细胞和基于动物的研究最近揭示了生物钟作为能量平衡的关键调节剂。不可避免地，遗传操纵生物钟成分的小鼠模型表现出脂质/脂肪酸代谢改变的特征，包括不同的肥胖和循环脂质。本文综述的目的是全面总结关于不同细胞自主生物钟调节脂肪酸代谢的最新知识。讨论了这些新发现对心血管代谢疾病和人类健康的影响。
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Regulation of fatty acid metabolism by cell autonomous circadian clocks: time to fatten up on information?细胞自主生物钟对脂肪酸代谢的调节：是时候从信息中获取营养了？
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