1型单纯疱疹病毒耐药株对5-碘-2'-脱氧尿苷或利巴韦林体外抗病毒活性的耐药性发展比较。
Comparison of the development of resistant strains of Type 1 herpes simplex virus to in vitro antiviral activity of 5-iodo-2'-deoxyuridine or ribavirin.
作者信息
Huffman J H, Allen L B, Sidwell R W
出版信息
Ann N Y Acad Sci. 1977 Mar 4;284(1):233-8. doi: 10.1111/j.1749-6632.1977.tb21955.x.
Abstract
Exposure of HSV/1 to low concentrations of ribavirin during 4--5 passages does not produce ribavirin-resistant virus. IDU resistance was developed by HSV/1 while it was being passed simultaneously. This resistance was seen to develop in both KB and Vero cells. The IDU-resistant virus is also resistant to ribavirin in KB cells.
摘要
在4至5代传代过程中，让单纯疱疹病毒1型（HSV/1）接触低浓度的利巴韦林不会产生利巴韦林耐药病毒。在同时传代时，HSV/1产生了对碘苷（IDU）的耐药性。在KB细胞和非洲绿猴肾细胞（Vero细胞）中均观察到这种耐药性的产生。在KB细胞中，对IDU耐药的病毒对利巴韦林也耐药。
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