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针对流感核蛋白的Tc识别的低反应性MHC等位基因。

Low responder MHC alleles for Tc recognition of influenza nucleoprotein.

作者信息

Pala P, Askonas B A

出版信息

Immunogenetics. 1986;23(6):379-84. doi: 10.1007/BF00372670.

DOI:10.1007/BF00372670
PMID:3487504
Abstract

Since virus nucleoprotein is an important target antigen for anti-influenza cytotoxic T cells (Tc), we examined the genetics of Tc responses to this single viral protein to find three nonresponder alleles (Dd, Dk, and Kb) in three haplotypes and their recombinants so far tested. B10.A(5R) mice bearing nonresponder MHC class I antigen in the D and K regions show no anti-NP Tc responses, however they do show a strong A-virus cross-reactive anti-influenza cytotoxicity. The high frequency of nonresponsiveness to a single viral component, as compared with the entire virus, has implications for the development of simple vaccines.

摘要

由于病毒核蛋白是抗流感细胞毒性T细胞（Tc）的重要靶抗原，我们研究了针对这种单一病毒蛋白的Tc反应的遗传学，以在三种单倍型及其重组体中找到三个无反应等位基因（Dd、Dk和Kb）。在D区和K区携带无反应性MHC I类抗原的B10.A(5R)小鼠没有抗NP Tc反应，然而它们确实表现出强烈的A病毒交叉反应性抗流感细胞毒性。与整个病毒相比，对单一病毒成分无反应的高频率对简单疫苗的开发具有启示意义。

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1
Low responder MHC alleles for Tc recognition of influenza nucleoprotein.针对流感核蛋白的Tc识别的低反应性MHC等位基因。
Immunogenetics. 1986;23(6):379-84. doi: 10.1007/BF00372670.
2
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3
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2
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本文引用的文献

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Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D ( k ).鼠细胞毒性 T 细胞对甲病毒的反应主要与 H-2D(k) 相关。
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Cross-protection and cross-reactive cytotoxic T cells induced by influenza virus vaccines in mice.流感病毒疫苗在小鼠中诱导的交叉保护和交叉反应性细胞毒性T细胞。
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Recognition of Db and Kb gene products by influenza-specific cytotoxic T cells.流感特异性细胞毒性T细胞对Db和Kb基因产物的识别。
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Anti-influenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a nonstructural protein: responsiveness to individual viral antigens is major histocompatibility complex controlled.抗流感病毒细胞毒性T淋巴细胞识别三种病毒聚合酶和一种非结构蛋白：对单个病毒抗原的反应性受主要组织相容性复合体控制。
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Class I MHC molecules rather than other mouse genes dictate influenza epitope recognition by cytotoxic T cells.I类主要组织相容性复合体（MHC）分子而非其他小鼠基因决定了细胞毒性T细胞对流感抗原表位的识别。
Immunogenetics. 1987;26(4-5):267-72. doi: 10.1007/BF00346521.
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Recognition of influenza virus proteins by cytotoxic T lymphocytes.细胞毒性T淋巴细胞对流感病毒蛋白的识别。
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Use of synthetic peptides of influenza nucleoprotein to define epitopes recognized by class I-restricted cytotoxic T lymphocytes.利用流感病毒核蛋白的合成肽来确定由I类限制性细胞毒性T淋巴细胞识别的表位。
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9
The 22,000-kilodalton protein of respiratory syncytial virus is a major target for Kd-restricted cytotoxic T lymphocytes from mice primed by infection.呼吸道合胞病毒的22000千道尔顿蛋白是受感染引发的小鼠中Kd限制细胞毒性T淋巴细胞的主要靶点。
J Virol. 1990 Apr;64(4):1683-9. doi: 10.1128/JVI.64.4.1683-1689.1990.
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Class I H-2d-restricted cytotoxic T lymphocytes recognize the neuraminidase glycoprotein of influenza virus subtype N1.I类H-2d限制性细胞毒性T淋巴细胞识别甲型流感病毒N1亚型的神经氨酸酶糖蛋白。
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Immunogenetics. 1983;17(3):283-94. doi: 10.1007/BF00364412.
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Recombinant vaccinia virus primes and stimulates influenza haemagglutinin-specific cytotoxic T cells.重组痘苗病毒引发并刺激流感血凝素特异性细胞毒性T细胞。
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H-2L-restricted recognition of viral antigens In the H-2d haplotype, anti-vesicular stomatitis virus cytotoxic T cells are restricted solely by H-2L.H-2L对病毒抗原的限制性识别 在H-2d单倍型中，抗水泡性口炎病毒细胞毒性T细胞仅受H-2L的限制。
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Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions.甲型流感病毒特异性杀伤性T细胞克隆的生物学特性。体内病毒复制的抑制及迟发型超敏反应的诱导。
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Domain interactions of H-2 class I antigens alter cytotoxic T-cell recognition sites.H-2 Ⅰ类抗原的结构域相互作用改变细胞毒性T细胞识别位点。
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