Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis and Alvin J Siteman Cancer Center, 660 S Euclid Avenue, Box 8100, St Louis, MO 63110, USA.
Br J Cancer. 2011 Mar 1;104(5):882-5. doi: 10.1038/sj.bjc.6606045. Epub 2011 Feb 8.
Little evidence is available on the relation of physical activity with colon adenomas, a colon cancer precursor.
We conducted a systematic literature review and meta-analysis of published studies (in English) through April 2010, examining physical activity or exercise and risk or prevalence of colon adenoma or polyp. Random effects models were used to estimate relative risks (RRs) and corresponding confidence intervals (CIs). A total of 20 studies were identified that examined the association and provided RRs and corresponding 95% CIs.
A significant inverse association between physical activity and colon adenomas was found with an overall RR of 0.84 (CI: 0.77-0.92). The association was similar in men (RR=0.81, CI: 0.67-0.98) and women (RR=0.87, CI: 0.74-1.02). The association appeared slightly stronger in large/advanced polyps (RR=0.70, CI: 0.56-0.88).
This study confirms previous reports of a significant inverse association of physical activity and colon adenoma, and suggests that physical activity can have an important role in colon cancer prevention.
关于体力活动与结肠癌前体——结肠腺瘤的关系，目前仅有少量证据。
我们对截至 2010 年 4 月已发表的相关文献进行了系统性回顾和荟萃分析，以评估体力活动或锻炼与结肠腺瘤或息肉的风险或发生率之间的关系。采用随机效应模型来估计相对风险（RR）及其相应的置信区间（CI）。共纳入 20 项研究，评估了体力活动与结肠腺瘤之间的关联性，并提供了 RR 及其相应的 95%CI。
总体 RR 为 0.84（95%CI：0.77-0.92），表明体力活动与结肠腺瘤之间存在显著的负相关关系。这种关联在男性（RR=0.81，95%CI：0.67-0.98）和女性（RR=0.87，95%CI：0.74-1.02）中均相似。在大型/晚期息肉中，这种关联似乎更强（RR=0.70，95%CI：0.56-0.88）。
本研究证实了以往关于体力活动与结肠腺瘤之间存在显著负相关关系的报告，并提示体力活动可能在结肠癌的预防中发挥重要作用。
