Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, USA.
J Nat Prod. 2013 Jan 25;76(1):91-6. doi: 10.1021/np3007606. Epub 2013 Jan 14.
During a survey of actinobacteria known to suppress the growth of Streptomyces scabies (the causative agent of potato scab disease) in vivo, six new rhamnosylated alkaloids, the solphenazines A-F (1-6), were isolated from a biological control strain of Streptomyces (DL-93). The known rhamnosyl analogue of paraben (9) was also isolated along with a new rhamnosylated derivative of N-methyl-p-aminobenzoic acid (10). None of the compounds exhibited any antibacterial or antifungal activity against a standard panel of microorganisms, but compounds 1, 2, and 6 displayed some cytotoxicity against HCT-116 cancer cells. Additional in vitro testing provided data suggesting that the cytotoxic activity is not due to DNA intercalation or topoisomerase inhibition.
在一项针对体内抑制马铃薯疮痂病病原体——疮痂链霉菌生长的放线菌的调查中，从一种生物防治链霉菌（DL-93）中分离到六种新的鼠李糖基生物碱，即索酚嗪 A-F（1-6）。此外，还分离到了已知的对羟基苯甲酸的鼠李糖基类似物（9）和 N-甲基-p-氨基苯甲酸的新的鼠李糖基衍生物（10）。这些化合物均对标准微生物面板没有任何抗菌或抗真菌活性，但化合物 1、2 和 6 对 HCT-116 癌细胞显示出一定的细胞毒性。进一步的体外测试提供的数据表明，细胞毒性活性不是由于 DNA 插入或拓扑异构酶抑制引起的。
