Institute of Health Science, Kyushu University, Fukuoka, Japan.
J Physiol Anthropol. 2011;30(1):15-22. doi: 10.2114/jpa2.30.15.
The aim of this cross-sectional study was to examine the factors which may be associated with the metabolic syndrome by exploring the relationship between psychosocial stress, age, body mass index (BMI), C-reactive protein (CRP), lifestyle factors, and the components of the metabolic syndrome, such as glycated hemoglobin (HbA1c), fasting blood sugar (FBS), body fat percentage, and triglyceride concentration, among apparently healthy subjects. Psychosocial stress was measured by the use of the inventory to measure psychosocial stress (IMPS). One thousand four hundred and ninety-nine people out of 1,941 public school workers admitted to a hospital for a medical check-up responded to the IMPS, yielding a response rate of 77.2%. A total of 1,201 workers excluding 298 who were taking medication for various diseases were analyzed with the use of hierarchical multiple regression models. It was found that IMPS-measured stress score, age, BMI, and smoking habit were associated with an increase in glycated hemoglobin among men, while alcohol consumption was associated with a decrease in glycated hemoglobin. Stress score, age, BMI, and alcohol consumption were found to be associated with an increase in FBS among men, while smoking and exercise habits were associated with a decrease in FBS. CRP was found to be associated with an increase in body fat percentage among men, though stress score was not associated with an increase in body fat percentage. Stress score, age, and BMI were associated with an increase in triglyceride concentration among women. The findings of the present study seem to be in line with the hypothesis that psychosocial stress plays an important role in developing the metabolic syndrome, which may be associated with inflammatory processes in the vascular wall, resulting in atherosclerosis and cardiovascular disease.
本横断面研究旨在通过探讨心理社会压力与年龄、体重指数 (BMI)、C 反应蛋白 (CRP)、生活方式因素以及代谢综合征各组分（如糖化血红蛋白 (HbA1c)、空腹血糖 (FBS)、体脂百分比和甘油三酯浓度）之间的关系，来研究可能与代谢综合征相关的因素。心理社会压力采用心理社会压力量表 (IMPS) 进行测量。在 1941 名参加医院体检的公立学校工作人员中，有 1499 人对 IMPS 做出了回应，回应率为 77.2%。共有 1201 名工作人员（298 名正在服用各种疾病药物的人员除外）被纳入分层多重回归模型进行分析。结果发现，IMPS 测量的压力评分、年龄、BMI 和吸烟习惯与男性糖化血红蛋白升高有关，而饮酒与糖化血红蛋白降低有关。压力评分、年龄、BMI 和饮酒与男性 FBS 升高有关，而吸烟和运动习惯与 FBS 降低有关。CRP 与男性体脂百分比升高有关，而压力评分与体脂百分比升高无关。压力评分、年龄和 BMI 与女性甘油三酯浓度升高有关。本研究结果似乎与心理社会压力在代谢综合征发展中起重要作用的假说一致，这可能与血管壁的炎症过程有关，导致动脉粥样硬化和心血管疾病。
