植物甾醇与青少年II型高脂蛋白血症
Sitosterol in juvenile type II hyperlipoproteinemia.
作者信息
Schlierf G, Oster P, Heuck C C, Raetzer H, Schellenberg B
出版信息
Atherosclerosis. 1978 Aug;30(4):245-8. doi: 10.1016/0021-9150(78)90116-8.
The effect of beta-sitosterol on plasma lipids and lipoproteins was evaluated in a randomized double-blind cross-over trial in 15 children and adolescents with familial hypercholesterolemia over a period of 6 months. Twelve patients completed the study, with good adherence to drug intake. Sitosterol lowered the plasma total choelsterol by 6%, LDL cholesterol by 7% and HDL cholesterol by 15% (P less than 0.05). This insufficient response of total and LDL cholesterol and the marked fall of HDL cholesterol appears to advise against the use of beta-sitosterol granulate in juvenile type II hyperlipoproteinemia.
在一项为期6个月的随机双盲交叉试验中，对15名患有家族性高胆固醇血症的儿童和青少年评估了β-谷甾醇对血浆脂质和脂蛋白的影响。12名患者完成了研究，药物摄入依从性良好。谷甾醇使血浆总胆固醇降低了6%，低密度脂蛋白胆固醇降低了7%，高密度脂蛋白胆固醇降低了15%（P<0.05）。总胆固醇和低密度脂蛋白胆固醇的这种不足反应以及高密度脂蛋白胆固醇的显著下降似乎提示不建议在青少年II型高脂蛋白血症中使用β-谷甾醇颗粒剂。
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