Catholic University of Brasília, 71966-700 Brasília, DF, Brazil.
Federal University of Juiz de Fora, 36036-330 Governador Valadares, MG, Brazil.
J Immunol Res. 2015;2015:724982. doi: 10.1155/2015/724982. Epub 2015 Oct 7.
Failure in antimicrobial activity contributes to high morbidity and mortality in the geriatric population. Little is known about the potential effect of resistance training (RT) on the functional properties of the innate immunity. This study aimed to investigate the influence of long-term RT on the endocytic and oxidative activities of neutrophils and monocytes in healthy older women. Our results indicate that the phagocytosis index (PhI) of neutrophils (but not of monocytes) in the RT-adapted group was significantly higher (P < 0.001; effect size, (d) = 0.90, 95% CI: [0.75-1.04]) compared to that in sedentary subjects. In contrast, the oxidative activity of either neutrophils or monocytes was not significantly influenced by RT. Also, total energy and carbohydrate intake as well as serum IL6 levels had a significant influence on the phagocytic activity of neutrophils (P = 0.04), being considered in the model. Multivariate regression identified the physical condition of the subject (β = 0.425; P = 0.01) as a significant predictor of PhI. In conclusion, circulating neutrophils of older women adapted to a long-term RT program expressed higher phagocytic activity.
抗菌活性的失败导致老年人群的高发病率和死亡率。对于阻力训练（RT）对先天免疫的功能特性的潜在影响知之甚少。本研究旨在调查长期 RT 对健康老年女性中性粒细胞和单核细胞的胞饮和氧化活性的影响。我们的结果表明，适应 RT 组的中性粒细胞（而非单核细胞）的吞噬指数（PhI）明显更高（P < 0.001；效应大小，（d）= 0.90，95%CI：[0.75-1.04]）与久坐组相比。相比之下，RT 对中性粒细胞或单核细胞的氧化活性没有明显影响。此外，总能量和碳水化合物摄入量以及血清 IL6 水平对中性粒细胞的吞噬活性有显著影响（P = 0.04），并在模型中进行了考虑。多元回归确定了受试者的身体状况（β=0.425；P=0.01）是 PhI 的重要预测因子。总之，适应长期 RT 计划的老年女性循环中性粒细胞表现出更高的吞噬活性。
