抗阻训练可降低肥胖绝经后女性的亚临床炎症。
Resistance training reduces subclinical inflammation in obese, postmenopausal women.
机构信息
Exercise Physiology Laboratory, Texas Christian University, Fort Worth, TX, USA.
出版信息
Med Sci Sports Exerc. 2012 Nov;44(11):2099-110. doi: 10.1249/MSS.0b013e3182644984.
PURPOSE
Aerobic exercise is frequently prescribed to reduce inflammatory-related disease (cardiovascular disease and diabetes) risk. Resistance training (RT), however, may be key to maximizing anti-inflammatory benefits of consistent exercise. We examined the influence of RT on inflammatory biomarkers in obese, postmenopausal women.
METHODS
Twenty-three women (65.6 ± 2.6 yr; body mass index, 33 kg·m) underwent 12 wk of RT (3 sets, 10 exercises, 3× per week, 8-12 repetition maximum (RM), resistance exercise (EX), N = 11) or social interaction intervention (SI, stretching, knitting, health lectures, 2× per week, control group (CON), N = 12). Both before (BT) and after (AT) RT or SI, blood was collected before (PR), immediately (PO), 2 h (2H), and 24 h (24H) after a single resistance exercise bout (RE) in EX and at the same time points in nonexercise, resting CON. For all time points, blood was analyzed for IL-6, leptin, and lipopolysaccharide (LPS)-stimulated tumor necrosis factor-α (TNF-α) (LPS-TNF) and IL-10 (LPS-IL10). PR samples were also examined for C-reactive protein, TNF-α, and adiponectin, and mRNA expression of toll-like receptor 4 (TLR4) and MC1R. Subcutaneous adipose tissue was extracted BT and AT and analyzed for mRNA expression of monocyte chemotactic protein-1, leptin, CD68, and TLR4.
RESULTS
RT improved strength (44%) and reduced circulating C-reactive protein (-33%), leptin (-18%) and TNF-α (-29%) with no change in body composition. IL-6 decreased after SI in CON (-17%). LPS-TNF increased after SI or RT (CON +26%, EX +67%, respectively), whereas LPS-IL10 decreased in CON (-28%) but increased in EX (+20%). RT did not influence inflammatory biomarker gene expression in whole blood or subcutaneous adipose tissue. A single RE bout augmented LPS-TNF and LPS-IL10 at 24H in EX, particularly AT.
CONCLUSION
RT reduced markers of subclinical inflammation in circulation in obese, postmenopausal women in the absence of changes in body composition. Chronic RT also enhanced response to endotoxin challenge both at rest (PR) and 24 h after an acute RE bout (24H).
目的
有氧运动常被用于降低与炎症相关的疾病（心血管疾病和糖尿病）风险。然而，抗阻训练（RT）可能是最大限度发挥持续运动抗炎益处的关键。本研究旨在探讨 RT 对肥胖绝经后女性炎症生物标志物的影响。
方法
23 名女性（65.6±2.6 岁；体重指数 33kg·m）进行了 12 周的 RT（3 组，10 项运动，每周 3 次，8-12 次重复最大（RM），阻力运动（EX），n=11）或社会互动干预（SI，拉伸、编织、健康讲座，每周 2 次，对照组（CON），n=12）。在 RT 或 SI 前后（BT 和 AT），在 EX 中单次抗阻运动后即刻（PO）、2 小时（2H）和 24 小时（24H）以及在非运动、休息时的 CON 中（BT 和 AT）的同一时间点采集血液。对于所有时间点，均分析血液中白细胞介素 6（IL-6）、瘦素、脂多糖（LPS）刺激的肿瘤坏死因子-α（LPS-TNF）和 IL-10（LPS-IL10）。PR 样本还检测了 C 反应蛋白、TNF-α和脂联素，并检测了 toll 样受体 4（TLR4）和 MC1R 的 mRNA 表达。BT 和 AT 时提取皮下脂肪组织，分析单核细胞趋化蛋白-1、瘦素、CD68 和 TLR4 的 mRNA 表达。
结果
RT 提高了力量（44%），降低了循环 C 反应蛋白（-33%）、瘦素（-18%）和 TNF-α（-29%），而身体成分没有变化。CON 中的 SI 后 IL-6 降低（-17%）。SI 或 RT 后 LPS-TNF 增加（CON+26%，EX+67%），而 CON 中 LPS-IL10 降低（-28%），EX 中增加（+20%）。RT 并未影响全血或皮下脂肪组织中炎症生物标志物基因的表达。单次 RE 可增强 EX 中 LPS-TNF 和 LPS-IL10 在 24 小时时的反应，尤其是 AT。
结论
在肥胖绝经后女性中，RT 降低了循环中亚临床炎症标志物，而身体成分无变化。慢性 RT 还增强了静息时（PR）和急性 RE 后 24 小时（24H）内对内毒素的反应。
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