Probo M, Cairoli F, Kindahl H, Faustini M, Galeati G, Veronesi M C
Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.
Reprod Domest Anim. 2011 Dec;46(6):1004-10. doi: 10.1111/j.1439-0531.2011.01775.x. Epub 2011 Mar 14.
In this study, 31 pregnant Alpine does were used to investigate the peripartal plasma profiles of progesterone, estradiol-17β, 15-ketodihydro-PGF(2α) and cortisol, assessing differences between goats with physiological and pathological parturition. The goats were observed around the time of parturition; all peripartum abnormalities were recorded, and veterinary assistance was provided if necessary. Blood samples were collected every 12 h from 7 days before to 7 days after delivery, and plasma used for hormonal analysis by radioimmunoassay. Two animals died during the study, and their data were excluded from the study. Of the remaining 29 animals, 23 goats had a spontaneous and physiological delivery, while six goats showed pathological parturition, including dystocia and retained placenta. The 65 alive kids were viable at birth and at 7 days of age. The results concerning the hormonal concentrations in the normal parturition confirm and define more precisely the patterns already described in the goat, while the comparison between physiological and pathological parturition has never been previously reported in this species. Highest peripartum levels of cortisol were found in the pathological group at delivery (30.6 vs 15.9 ng/ml) (p<0.01) and 12 h later (26.2 vs 11.1 ng/ml) (p<0.05); the greater cortisol concentrations found in goats with dystocia and retained placenta could suggest a higher level of stress. No significant differences between the two groups were found with respect to the circulating values of the other hormones, but the individual variability and the small number of goats enrolled in the pathological delivery group could have masked possible differences.
在本研究中，选用31只怀孕的阿尔卑斯山羊来调查围产期血浆中孕酮、雌二醇-17β、15-酮二氢-PGF(2α)和皮质醇的水平，评估生理分娩和病理分娩山羊之间的差异。在分娩前后观察这些山羊；记录所有围产期异常情况，必要时提供兽医协助。从分娩前7天至分娩后7天，每12小时采集一次血样，血浆用于放射免疫分析法进行激素分析。研究期间有2只动物死亡，其数据被排除在研究之外。在其余29只动物中，23只山羊自然顺产，6只山羊出现病理分娩，包括难产和胎盘滞留。65只存活的羔羊出生时及7日龄时均存活。正常分娩时激素浓度的结果证实并更精确地定义了山羊中已描述的模式，而生理分娩和病理分娩之间的比较此前在该物种中从未报道过。病理组在分娩时（30.6对15.9 ng/ml）（p<0.01）和12小时后（26.2对11.1 ng/ml）（p<0.05）皮质醇的围产期水平最高；难产和胎盘滞留山羊中发现的皮质醇浓度较高可能表明应激水平较高。两组在其他激素的循环值方面未发现显著差异，但个体变异性以及病理分娩组纳入的山羊数量较少可能掩盖了潜在差异。
